Kamemoto E S, Atkinson D E
Arch Biochem Biophys. 1985 Nov 15;243(1):100-7. doi: 10.1016/0003-9861(85)90777-5.
Acetylglutamate is known to modulate the activity of carbamyl phosphate synthetase, and thus probably to participate in regulation of the urea cycle. Therefore factors that regulate the activity of acetylglutamate synthase are relevant to control of urea synthesis and of systemic pH. An increase in the concentration of arginine increases both Vmax and S0.5 for glutamate of acetylglutamate synthase from rat liver. An increase in pH causes S0.5 for glutamate to decrease and does not affect Vmax. As a consequence of these effects, a rapid rate of synthesis of acetylglutamate requires a concentration of arginine of about 25 microM or higher and either relatively high glutamate concentrations or relatively high pH.
已知乙酰谷氨酸可调节氨甲酰磷酸合成酶的活性，因此可能参与尿素循环的调节。所以，调节乙酰谷氨酸合成酶活性的因素与尿素合成及全身pH值的控制相关。精氨酸浓度的增加会使大鼠肝脏乙酰谷氨酸合成酶对谷氨酸的Vmax和S0.5均升高。pH值升高会使谷氨酸的S0.5降低，而不影响Vmax。由于这些效应，快速合成乙酰谷氨酸需要精氨酸浓度约为25微摩尔或更高，以及相对较高的谷氨酸浓度或相对较高的pH值。
