Schwarz T, Gschnait F
Arch Dermatol. 1985 Dec;121(12):1512-5.
Anthralin minute entire skin treatment (AMEST) was developed to improve the efficacy and cosmetic results of anthralin short-contact therapy. In a split comparison study to determine the optimal period of anthralin application, ten minutes of anthralin contact time gave maximum antipsoriatic activity with minimal side effects. Dosimetry variables for AMEST were determined based on the patient's pigmentation type, the erythematous response, the therapeutic effect, and so on. Such treatment of 43 patients resulted in complete clearing in 31 patients (72%), with 90% improvement in two patients (5%) and less than 90% clearing in seven patients (16%). Psoriatic lesions disappeared, leaving no spotty pigmentation that is known to occur following conventional anthralin therapy. The dosimetry variables employed in our study allowed AMEST with minimal skin irritation. Laboratory values did not change significantly during therapy. In addition, AMEST does not involve systemic medication and is easy to perform without special equipment; therefore, it is economic and can be used for outpatients and probably for home treatment.
蒽林全皮肤微量治疗（AMEST）旨在提高蒽林短程接触疗法的疗效和美容效果。在一项旨在确定蒽林最佳涂抹时间的对比研究中，10分钟的蒽林接触时间产生了最大的抗银屑病活性且副作用最小。AMEST的剂量测定变量是根据患者的色素沉着类型、红斑反应、治疗效果等确定的。对43例患者进行这种治疗后，31例患者（72%）完全清除，2例患者（5%）改善90%以上，7例患者（16%）清除不到90%。银屑病皮损消失，未留下传统蒽林治疗后常见的点状色素沉着。我们研究中采用的剂量测定变量使AMEST对皮肤的刺激最小。治疗期间实验室检查值无明显变化。此外，AMEST无需全身用药，无需特殊设备即可轻松实施；因此，它经济实惠，可用于门诊患者，甚至可能用于家庭治疗。
