Higashi K, Katayama I, Nishioka K, Nishiyama S
Nihon Hifuka Gakkai Zasshi. 1989 Feb;99(2):129-34.
Anthralin therapy was used in 39 cases with psoriasis, 31 cases with large plaque type and 8 cases with small plaque type. The therapy was performed in 2 ways with 0.05-2% anthralin ointment: short contact therapy and long contact therapy. Both therapies worked equally well on psoriasis. Improvement was observed in 26 cases (67%); 7 cases did not respond to the anthralin therapy. In 6 cases it was difficult to assess its effect. The large plaque type of psoriasis responded better than the small plaque type and showed a much longer remission period. Of the improved cases with large plaque type, 45% had remission periods longer than 6 months. Skin irritation (29 cases) and pigmentation (20 cases) were the side effects of anthralin therapy. However, those side effects were avoided by starting the therapy with a lower concentration of anthralin ointment and increasing the concentration gradually. Short contact therapy enabled us to apply the ointment in an outpatient clinic. It is suggested that anthralin therapy should be applied more frequently to psoriasis.
蒽林疗法应用于39例银屑病患者，其中大斑块型31例，小斑块型8例。采用0.05 - 2%蒽林软膏以两种方式进行治疗：短程接触疗法和长程接触疗法。两种疗法对银屑病的疗效相同。26例（67%）病情有改善；7例对蒽林疗法无反应。6例难以评估其疗效。大斑块型银屑病的反应优于小斑块型，缓解期更长。在大斑块型病情改善的病例中，45%的缓解期超过6个月。皮肤刺激（29例）和色素沉着（20例）是蒽林疗法的副作用。然而，通过从低浓度蒽林软膏开始治疗并逐渐增加浓度可避免这些副作用。短程接触疗法使我们能够在门诊应用该软膏。建议更频繁地将蒽林疗法应用于银屑病。
