Getinet Mamaru, Jemal Mohammed, Baylie Temesgen, Wendmneh Bayu, Baye Gelagay, Asmare Derese Sinamaw, Getinet Muluken, Tegegne Bantayehu Addis, Belaineh Aysheshim, Fenta Mengistu Enyew, Azanaw Amare Gashaw, Adugna Adane, Hibstu Teffera Zigale, Belew Habtamu
Department of Biomedical Sciences, School of Medicine, Debre Markos University, Debre Markos, Ethiopia
Department of Biomedical Sciences, School of Medicine, Debre Markos University, Debre Markos, Ethiopia.
BMJ Open. 2025 Jul 6;15(7):e092760. doi: 10.1136/bmjopen-2024-092760.
This study aimed to assess high-risk human papillomavirus (HPV) infection (HPV 16/18) and its determinants among women in East Gojjam Zone, Northwest Ethiopia.
An institutional-based cross-sectional study.
The study was conducted among 337 women screened for cervical cancer in two hospitals in East Gojjam Zone from February to April 2021 gregoriean calander.
The prevalence of HPV infection was 14.2% (95% CI: 10.7% to 18.1%). The mean age of the respondents was 36.7±9.1 years. Women in the age group of 55-65 years (adjusted OR (AOR)=7.91, 95% CI: 1.95 to 32.09), early initiation of sexual intercourse (AOR=5.36, 95% CI: 1.58 to 18.13), history of sexually transmitted infection (STI) (AOR=3.52, 95% CI: 1.27 to 9.72), HIV positive status (AOR=6.8, 95% CI: 1.99 to 23.54) and number of lifetime sexual partners (AOR=4.37, 95% CI: 1.15 to 17.3) were important independent factors associated with the presence of oncogenic HPV infection.
We found a relatively low prevalence of high-risk HPV infection. Age, early initiation of sexual intercourse at less than 18 years, history of STI, being HIV seropositive and multiple sexual partners were important factors for high-risk HPV infection. Women aged >46 years, women with early initiation of sex, a history of STI, being HIV positive and a history of multiple sexual partners should be encouraged to be screened and vaccinated for HPV infection. Wider-ranging studies are also needed in HPV-infected women in association with the cervical lesion.
本研究旨在评估埃塞俄比亚西北部东戈贾姆地区女性高危型人乳头瘤病毒（HPV）感染（HPV 16/18）情况及其决定因素。
一项基于机构的横断面研究。
该研究于2021年2月至4月在东戈贾姆地区两家医院对337名接受宫颈癌筛查的女性进行。
HPV感染率为14.2%（95%置信区间：10.7%至18.1%）。受访者的平均年龄为36.7±9.1岁。55 - 65岁年龄组的女性（调整优势比（AOR）=7.91，95%置信区间：1.95至32.09）、过早开始性行为（AOR = 5.36，95%置信区间：1.58至18.13）、性传播感染（STI）病史（AOR = 3.52，95%置信区间：1.27至9.72）、HIV阳性状态（AOR = 6.8，95%置信区间：1.99至23.54）以及终身性伴侣数量（AOR = 4.37，95%置信区间：1.15至17.3）是与致癌性HPV感染存在相关的重要独立因素。
我们发现高危型HPV感染率相对较低。年龄、18岁以前过早开始性行为、性传播感染病史、HIV血清阳性以及多个性伴侣是高危型HPV感染的重要因素。应鼓励年龄大于46岁、过早开始性行为、有性传播感染病史、HIV阳性以及有多个性伴侣史的女性进行HPV感染筛查和接种疫苗。对于HPV感染女性及其宫颈病变还需要开展更广泛的研究。
