BACKGROUND

Pulmonary segmentectomy is increasingly recognized as a viable alternative to lobectomy for early stage non-small-cell lung cancer (NSCLC), offering comparable oncological outcomes with potentially reduced morbidity. Identifying reliable predictors for postoperative complications and prolonged air leak (PAL) is crucial for optimizing patient selection. While multifactorial scoring systems exist, their complexity limits clinical utility and the predictive value of single factors, such as forced expiratory volume in 1s () and diffusing capacity for carbon monoxide (DL), remains underexplored.

OBJECTIVES

This study aimed to evaluate the ability of preoperative and DL to predict complications (Clavien-Dindo ⩾ 3a) and PAL in patients undergoing pulmonary segmentectomy.

DESIGN

A retrospective, single-center study compared outcomes between patients undergoing segmentectomy ( = 33) and lobectomy ( = 126) for NSCLC.

METHODS

Patient characteristics, complication rates, and PAL incidence were analyzed. Logistic regression and ROC curve analyses assessed the predictive accuracy of and DL for complications and PAL.

RESULTS

Baseline characteristics, including and DL, were comparable between the segmentectomy and lobectomy groups ( > 0.05). was identified as a significant predictor of complications, with lower values associated with increased risk. DL exhibited an even stronger predictive value for complications in the segmentectomy cohort, with an AUC of 0.924, indicating excellent predictive accuracy. In contrast, neither nor DL demonstrated significant predictive value for PAL, which occurred in 30% of segmentectomy and 20% of lobectomy patients ( > 0.05).

CONCLUSION

Preoperative and DL are valuable predictors of complications (Clavien-Dindo ⩾ 3a) in pulmonary segmentectomy, with DL showing high predictive accuracy. However, their inability to reliably predict PAL highlights the need for multifactorial models to enhance risk assessment. Despite the limited sample size, our findings align with larger studies and reinforce the clinical utility of and DL for preoperative risk stratification in segmentectomy patients.