肝脏中跨细胞钙分布的肾上腺素能控制的证据。
Evidence for adrenergic control of transcellular calcium distribution in liver.
作者信息
Hill C E, Dawson A P, Pryor J S
出版信息
Biochem J. 1985 Sep 15;230(3):733-7. doi: 10.1042/bj2300733.
Abstract
Free Ca2+ concentration and 45Ca flux were measured in the perfusate and bile of the perfused rat liver. With a perfusate Ca2+ concentration of 1 mM, the bile concentration was 0.35 mM. The ratio of 45Ca in bile to that in blood increased from 0.3 to 0.6 over 90 min of perfusion. Both verapamil and adrenaline (via alpha-adrenergic receptors) increased the 45Ca bile/perfusate ratio to 0.8. Adrenaline infusion increased the bile Ca2+ concentration to 0.8 mM. This decreased to 0.35 mM after the infusion was stopped.
摘要
在灌注大鼠肝脏的灌注液和胆汁中测量了游离钙离子浓度和45钙通量。当灌注液中钙离子浓度为1 mM时，胆汁浓度为0.35 mM。在90分钟的灌注过程中，胆汁中45钙与血液中45钙的比值从0.3增加到0.6。维拉帕米和肾上腺素（通过α-肾上腺素能受体）均将45钙胆汁/灌注液比值提高到0.8。输注肾上腺素使胆汁钙离子浓度增加到0.8 mM。停止输注后，该浓度降至0.35 mM。
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