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血管紧张素II对肝细胞糖原分解的刺激可能涉及钙释放和钙内流。

Stimulation of glycogenolysis in hepatocytes by angiotensin II may involve both calcium release and calcium influx.

作者信息

DeWitt L M, Putney J W

出版信息

FEBS Lett. 1983 Aug 22;160(1-2):259-63. doi: 10.1016/0014-5793(83)80978-8.

DOI:10.1016/0014-5793(83)80978-8
PMID:6884512
Abstract

The stimulation of [3H]glucose release (a measure of glycogenolysis) from isolated guinea pig hepatocytes by Ca-mobilizing agonists can be resolved into two phases. The initial transient phase is independent of extracellular Ca, and is probably a result of Ca released from an intracellular pool. The second phase occurs only in the presence of extracellular Ca, which suggests that Ca-influx is also involved in the mechanism of Ca-mobilization by these agents in the guinea pig hepatocyte.

摘要

通过钙动员激动剂刺激分离的豚鼠肝细胞释放[3H]葡萄糖（糖原分解的一种测量指标）可分为两个阶段。最初的瞬时阶段与细胞外钙无关，可能是细胞内钙库释放钙的结果。第二阶段仅在细胞外钙存在时发生，这表明钙内流也参与了这些试剂在豚鼠肝细胞中钙动员的机制。

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1
Stimulation of glycogenolysis in hepatocytes by angiotensin II may involve both calcium release and calcium influx.血管紧张素II对肝细胞糖原分解的刺激可能涉及钙释放和钙内流。
FEBS Lett. 1983 Aug 22;160(1-2):259-63. doi: 10.1016/0014-5793(83)80978-8.
2
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引用本文的文献

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Evidence that a pertussis-toxin-sensitive substrate is involved in the stimulation by epidermal growth factor and vasopressin of plasma-membrane Ca2+ inflow in hepatocytes.
有证据表明，一种对百日咳毒素敏感的底物参与了表皮生长因子和血管加压素对肝细胞质膜Ca2+内流的刺激作用。
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