Khanolkar Amal R, Karamanos Alexis, Becares Laia
Department of Population Health Sciences, Guy's Campus, King's College London, London, UK.
Department of Global Health and Social Medicine, King's College London, Strand Campus, King's College London, London, UK.
BMC Med. 2025 Jul 9;23(1):417. doi: 10.1186/s12916-025-04236-2.
Mental health problems (MHP, like depression/anxiety) and health and risk behaviours (HRBs) are more common among sexual minority adolescents (SMA) than in heterosexual peers. Limited studies have examined the co-occurrence of poor mental health and HRBs, if co-occurrence differs by sexual identity, and associated risks for self-harm and attempted suicide in adolescents.
This study included 10,233 adolescents aged 17 years (51% female/11% sexual minority) from the UK-wide Millennium Cohort Study. Sexual identity, MHP, seven HRBs (like regular smoking, drug use and sexual risk behaviour), self-harm and attempted suicide were self-reported. MHP were assessed using the strengths and difficulties questionnaire [SDQ] emotional symptoms subscale for depression/anxiety. We assessed associations between sexual identity and co-occurrence of MHP and HRBs using multinomial logistic regression. We estimated predicted probabilities for self-harm or attempted suicide based on sexual identity and MHP-HRB co-occurrence status using logistic regression models with appropriate interaction terms (between sexual identity and MHP-HRB co-occurrence status variables).
MHP prevalence was higher in gay/lesbian (48%) and bisexual (49%) adolescents compared to heterosexual peers (19%). Self-harm (bisexual, 64%; gay/lesbian, 53%; heterosexual, 19%) and attempted suicide (bisexual, 24%; gay/lesbian, 17%; heterosexual, 6%) prevalence were higher in SMA compared to heterosexual peers. Gay/lesbian and bisexual adolescents consistently had higher probability for MHP-HRB co-occurrence compared to heterosexual peers (example, for gay/lesbian individuals: RRR 3.16 [95% CI 2.1-4.68] for MHP-1HRB, RRR 3.54 [95% CI 2.06-6.08] for MHP- ≥ 3HRB, for bisexual adolescents: RRR 2.44 [95% CI 1.85-3.20] for MHP-1HRB, RRR 4.11 [95% CI 2.99-5.66] for MHP- ≥ 3HRB). MHP-HRB co-occurrence and sexual minority identity were independently associated with greater odds for self-harm or attempted suicide. SMA had higher probabilities of reporting self-harm than heterosexual peers with the same level of MHP-HRB co-occurrence. For example, 37.2% of heterosexual adolescents with MHP-1HRB reported self-harm. Corresponding numbers were twice as high in bisexual (75.7%) and gay/lesbian (77.9%) individuals. Similarly, 58.3% of heterosexual adolescents with MHP- ≥ 3HRBs reported self-harm, increasing to 84.6% in bisexual and 83.8% in gay/lesbian peers.
SMA are more likely to experience MHP-HRB co-occurrence, which is associated with substantially higher risks for self-harm and attempted suicide compared to heterosexual peers. Findings highlight the need for better public health policies to address MHP and associated comorbidities to reduce sexual identity-related health inequities in adolescence.
心理健康问题(如抑郁症/焦虑症)以及健康与风险行为在性少数青少年中比在异性恋同龄人中更为常见。仅有有限的研究探讨了心理健康不佳与健康和风险行为的共现情况,这种共现是否因性取向而异,以及青少年自我伤害和自杀未遂的相关风险。
本研究纳入了来自全英国千禧世代研究的10233名17岁青少年(51%为女性/11%为性少数群体)。性取向、心理健康问题、七种健康与风险行为(如经常吸烟、吸毒和性风险行为)、自我伤害和自杀未遂情况均通过自我报告获得。心理健康问题使用长处和困难问卷[SDQ]中关于抑郁症/焦虑症的情绪症状子量表进行评估。我们使用多项逻辑回归评估性取向与心理健康问题和健康与风险行为共现之间的关联。我们基于性取向以及心理健康问题与健康和风险行为的共现状况,使用带有适当交互项(性取向与心理健康问题 - 健康和风险行为共现状况变量之间)的逻辑回归模型,估计自我伤害或自杀未遂的预测概率。
与异性恋同龄人(19%)相比,男同性恋/女同性恋(48%)和双性恋(49%)青少年的心理健康问题患病率更高。与异性恋同龄人相比,性少数青少年的自我伤害(双性恋为64%;男同性恋/女同性恋为53%;异性恋为19%)和自杀未遂(双性恋为24%;男同性恋/女同性恋为17%;异性恋为6%)患病率更高。与异性恋同龄人相比,男同性恋/女同性恋和双性恋青少年心理健康问题与健康和风险行为共现的概率始终更高(例如,对于男同性恋/女同性恋个体:心理健康问题与一种健康和风险行为共现的相对危险度[RRR]为3.16[95%置信区间2.1 - 4.68],心理健康问题与三种及以上健康和风险行为共现的RRR为3.54[95%置信区间2.06 - 6.08];对于双性恋青少年:心理健康问题与一种健康和风险行为共现的RRR为2.44[95%置信区间1.85 - 3.20],心理健康问题与三种及以上健康和风险行为共现的RRR为4.11[95%置信区间2.99 - 5.66])。心理健康问题与健康和风险行为的共现以及性少数群体身份独立地与更高的自我伤害或自杀未遂几率相关。在心理健康问题与健康和风险行为共现水平相同的情况下,性少数青少年报告自我伤害的概率高于异性恋同龄人。例如,有心理健康问题与一种健康和风险行为共现的异性恋青少年中,37.2%报告有自我伤害行为。双性恋(75.7%)和男同性恋/女同性恋(77.9%)个体的相应比例是其两倍。同样,有心理健康问题与三种及以上健康和风险行为共现的异性恋青少年中,58.3%报告有自我伤害行为,双性恋同龄人中这一比例增至84.6%,男同性恋/女同性恋同龄人中为83.8%。
性少数青少年更有可能出现心理健康问题与健康和风险行为的共现,与异性恋同龄人相比,这与显著更高的自我伤害和自杀未遂风险相关。研究结果凸显了制定更好的公共卫生政策以解决心理健康问题及相关合并症的必要性,以减少青春期与性取向相关的健康不平等现象。