Intestinal epithelium cells-derived extracellular vesicles: A new mediator of intestinal information transmission.
作者信息
Han Xue, Yang Yaxu, Sun Lijun, Shao Fangyu, Zhang Weizhen, Yin Yue
机构信息
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
出版信息
Chin Med J (Engl). 2025 Aug 20;138(16):1891-1893. doi: 10.1097/CM9.0000000000003692. Epub 2025 Jul 9.
Abstract
摘要
相似文献
1
Intestinal epithelium cells-derived extracellular vesicles: A new mediator of intestinal information transmission.肠道上皮细胞衍生的细胞外囊泡：肠道信息传递的新介质
Chin Med J (Engl). 2025 Aug 20;138(16):1891-1893. doi: 10.1097/CM9.0000000000003692. Epub 2025 Jul 9.
2
Bacterial extracellular vesicles in the brain: Pathological effects and therapeutic possibilities.大脑中的细菌细胞外囊泡：病理影响与治疗潜力
Neural Regen Res. 2025 Jun 19. doi: 10.4103/NRR.NRR-D-25-00236.
3
Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome.间充质基质细胞衍生的细胞外囊泡减轻急性辐射综合征小鼠模型的肠道毒性。
Stem Cell Res Ther. 2020 Aug 27;11(1):371. doi: 10.1186/s13287-020-01887-1.
4
Extracellular Vesicles Derived From Modulate Inflammatory Genes and Tight Junctions in a Human Model of Intestinal Epithelium.源自[具体内容缺失]的细胞外囊泡在人肠上皮模型中调节炎症基因和紧密连接。
Front Nutr. 2021 Nov 24;8:778998. doi: 10.3389/fnut.2021.778998. eCollection 2021.
5
Characterisation of LPS+ bacterial extracellular vesicles along the gut-hepatic portal vein-liver axis.肠-肝门静脉-肝轴中 LPS+细菌细胞外囊泡的特征。
J Extracell Vesicles. 2024 Jul;13(7):e12474. doi: 10.1002/jev2.12474.
6
The Role of Epithelial-Derived Extracellular Vesicles in Allergic Sensitisation: A Systematic Review.上皮来源的细胞外囊泡在过敏性致敏中的作用：一项系统综述。
Int J Mol Sci. 2025 Jun 17;26(12):5791. doi: 10.3390/ijms26125791.
7
Circ-0000197 derived from porcine milk small extracellular vesicles promotes intestinal barrier function by sponging miR-429.源自猪乳小细胞外囊泡的Circ-0000197通过吸附miR-429促进肠道屏障功能。
J Anim Sci Biotechnol. 2025 Jun 25;16(1):89. doi: 10.1186/s40104-025-01218-5.
8
Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLRP3 inflammasome suppression.内脏气味杆菌衍生的细胞外囊泡通过抑制NLRP3炎性小体调节胃肠道炎症和肠道屏障功能，从而缓解炎症性肠病。
Mol Med. 2025 Feb 11;31(1):56. doi: 10.1186/s10020-025-01063-2.
9
Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization.腹泻微生物群衍生的细胞外囊泡通过miR-125b/核因子κB介导的巨噬细胞极化导致肠道稳态功能障碍。
Gut Microbes. 2025 Dec;17(1):2541036. doi: 10.1080/19490976.2025.2541036. Epub 2025 Jul 30.
10
Assessing Extracellular Vesicle-Host Interaction Using a Microfluidic Platform with Caco-2 Spheroides-on-Chip.使用带有芯片上Caco-2类球体的微流控平台评估细胞外囊泡与宿主的相互作用。
ACS Biomater Sci Eng. 2025 Aug 11;11(8):4818-4829. doi: 10.1021/acsbiomaterials.5c00750. Epub 2025 Jun 23.
本文引用的文献
1
Regulation of hepatic lipid metabolism by intestine epithelium-derived exosomes.肠上皮来源的外泌体对肝脏脂质代谢的调节
Life Metab. 2023 Nov 21;2(6):load044. doi: 10.1093/lifemeta/load044. eCollection 2023 Dec.
2
Engineered extracellular vesicles for tissue repair and regeneration.用于组织修复和再生的工程化细胞外囊泡。
Burns Trauma. 2024 Oct 22;12:tkae062. doi: 10.1093/burnst/tkae062. eCollection 2024.
3
Exosomal-miR-129-2-3p derived from -infected intestinal epithelial cells promotes experimental colitis through regulating TIMELESS-mediated cellular senescence pathway.源自 - 感染的肠道上皮细胞的外泌体 miR-129-2-3p 通过调节 TIMESLESS 介导的细胞衰老途径促进实验性结肠炎。
Gut Microbes. 2023 Jan-Dec;15(1):2240035. doi: 10.1080/19490976.2023.2240035.
4
Crohn's disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis.克罗恩病相关的 AIEC 通过抑制肠道上皮细胞衍生的外泌体 let-7b 的表达来调节巨噬细胞极化，从而加重肠道纤维化。
Gut Microbes. 2023 Jan-Dec;15(1):2193115. doi: 10.1080/19490976.2023.2193115.
5
Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via targeting MAP4K4.肠上皮细胞来源的包裹微小RNA-23a-3p的外泌体通过靶向丝裂原活化蛋白激酶4激酶4减轻缺血/再灌注后的肠道损伤。
Biomed Pharmacother. 2022 May;149:112810. doi: 10.1016/j.biopha.2022.112810. Epub 2022 Mar 15.
6
Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy.肠道上皮细胞外泌体引发脓毒症相关性脑病中 IL-1β 介导的神经元损伤。
Front Cell Infect Microbiol. 2022 Jan 17;11:783049. doi: 10.3389/fcimb.2021.783049. eCollection 2021.
7
High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance.高脂肪饮食诱导的外泌体磷脂酰胆碱上调导致胰岛素抵抗。
Nat Commun. 2021 Jan 11;12(1):213. doi: 10.1038/s41467-020-20500-w.
8
Intestinal Epithelium-Derived Luminally Released Extracellular Vesicles in Sepsis Exhibit the Ability to Suppress TNF-a and IL-17A Expression in Mucosal Inflammation.肠道上皮细胞衍生的腔内分泌细胞外囊泡在脓毒症中表现出抑制黏膜炎症中 TNF-a 和 IL-17A 表达的能力。
Int J Mol Sci. 2020 Nov 10;21(22):8445. doi: 10.3390/ijms21228445.
9
Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease.代谢蛋白质组学揭示了小儿炎症性肠病中微生物组与肠道细胞外囊泡蛋白之间的关联。
Nat Commun. 2018 Jul 20;9(1):2873. doi: 10.1038/s41467-018-05357-4.
10
Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction.肠上皮细胞衍生的外泌体触发创伤后免疫功能障碍。
J Trauma Acute Care Surg. 2018 Feb;84(2):257-264. doi: 10.1097/TA.0000000000001748.
Zotero 插件