三丁基锡对缺乏偶联因子的亚线粒体颗粒中能量偶联的作用。
The action of tributyltin on energy coupling in coupling-factor-deficient submitochondrial particles.
作者信息
Dawson A P, Selwyn M J
出版信息
Biochem J. 1975 Nov;152(2):333-9. doi: 10.1042/bj1520333.
Abstract
- Tributyltin at concentrations of approx. 1nmol/mg of protein induces respiratory control and lessens the protein permeability of coupling-factor-deficient submitochondrial particles. 2. At these concentrations or lower, it increases the P/O ratio of the particles to a small extent and inhibits the adenosine triphosphatase activity without greatly increasing its sensitivity to uncoupling agents. 3. It fails to stimulate ATP-driven reversed electron transport or transhydrogenase, but stimulates the transhydrogenase driven by aerobic succinate oxidation. 4. The results indicate that, unlike oligomycin, tributyltin does not discriminate between damaged and intact ATP-synthesizing complexes. 5. The relationship between the oligomycin- and tributyltin-binding sites is discussed.
摘要
- 浓度约为1纳摩尔/毫克蛋白质的三丁基锡可诱导呼吸控制，并降低偶联因子缺陷型亚线粒体颗粒的蛋白质通透性。2. 在这些浓度或更低浓度下，它会在一定程度上提高颗粒的P/O比值，并抑制腺苷三磷酸酶活性，而不会大幅增加其对解偶联剂的敏感性。3. 它无法刺激由ATP驱动的逆向电子传递或转氢酶，但能刺激由需氧琥珀酸氧化驱动的转氢酶。4. 结果表明，与寡霉素不同，三丁基锡不会区分受损和完整的ATP合成复合物。5. 讨论了寡霉素结合位点与三丁基锡结合位点之间的关系。
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