Bayer Arda, Salazar Betsy H, Hoffman Kris, Aazhang Behnaam, Khavari Rose
Rice University, Houston, TX.
Houston Methodist, Houston, TX.
Proc Des Med Devices Conf. 2025 Apr;2025. doi: 10.1115/dmd2025-1068. Epub 2025 May 24.
Current medical diagnosis and treatment methods for neurogenic lower urinary tract dysfunction (NLUTD) disorders are constrained by our limited understanding of how a set of the complex neural circuits that regulate the LUT function. Identifying robust biomarkers for perceived bladder sensation could be key to advancing diagnostic and therapeutic modalities for NLUTD. In this work, we applied a transfer learning approach to infer bladder fullness sensation from functional magnetic resonance imaging (fMRI) data. While the proposed approach effectively represented fMRI scans in the embedding space, it did not predict bladder fullness sensation significantly better than random chance.
目前,神经源性下尿路功能障碍(NLUTD)疾病的医学诊断和治疗方法受到限制,因为我们对调节下尿路功能的一组复杂神经回路的了解有限。识别出用于感知膀胱感觉的可靠生物标志物可能是推进NLUTD诊断和治疗方式的关键。在这项工作中,我们应用迁移学习方法从功能磁共振成像(fMRI)数据中推断膀胱充盈感觉。虽然所提出的方法在嵌入空间中有效地表示了fMRI扫描,但它对膀胱充盈感觉的预测并不比随机猜测显著更好。