White Callum M, Azimi Zohre, Staadt Robert, Song Chenchen, Knöpfel Thomas, Jancke Dirk
Optical Imaging Group, Institut für Neuroinformatik, Ruhr University Bochum, Germany.
Monoaminergic Neuronal Networks & Diseases (MoNN&Di), Ruhr University Bochum, Germany.
bioRxiv. 2025 Jul 6:2025.07.05.663288. doi: 10.1101/2025.07.05.663288.
Visual perception appears largely stable in time. However, psychophysical studies have revealed that theta waves (4-8 Hz) can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of theta waves to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal persistence of visually evoked 5-Hz oscillations. This modulation of 5-Hz oscillations in both cortical areas indicates a strengthening of top-down control of perception, supporting an underlying mechanism of perceptual filling and visual hallucinations.
视觉感知在时间上似乎很大程度上是稳定的。然而，心理物理学研究表明，θ波（4-8赫兹）可以调节感知，并与各种认知状态和功能相关联。在高时空尺度上，θ波对皮层活动的贡献及其在异常脑状态下的影响都尚未得到解决。在这里，我们使用清醒小鼠的全皮层群体电压成像，发现视觉皮层中5赫兹振荡的发作伴随着 retrosplenial 皮层中的类似振荡，这些振荡既可以自发出现，也可以由视觉刺激诱发。注射精神otropic 5-HT2AR 激动剂会导致自发5赫兹振荡显著增加，同时也增加了视觉诱发的5赫兹振荡的功率、发生概率和时间持续性。两个皮层区域中5赫兹振荡的这种调节表明自上而下的感知控制得到加强，支持了感知填充和视觉幻觉的潜在机制。
