Ng-Cordell Elise, Storch Eric A, Kendall Philip C, Wood Jeffrey J, Mikami Amori Yee, Kerns Connor M
Department of Psychology, University of British Columbia, Vancouver, BC, Canada.
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
J Child Psychol Psychiatry. 2025 Jul 9. doi: 10.1111/jcpp.70010.
Childhood mental health conditions commonly cooccur, with potential treatment implications. Autistic children frequently experience anxiety and attention deficit/hyperactivity disorder (ADHD). We investigated the implications of this cooccurrence for Cognitive Behavioural Therapy (CBT), a front-line treatment for anxiety in autistic children. We tested whether (1) ADHD predicts anxiety treatment response, (2) ADHD improves in response to anxiety treatment and (3) ADHD improvement is related to reductions in anxiety.
Autistic children with elevated anxiety (N = 167) enrolled in a multisite, randomised controlled trial comparing standard CBT, autism-adapted CBT and treatment as usual. ADHD symptoms and severity were assessed via a parent-report questionnaire and clinical interview, respectively. Linear regressions (questions 1 and 2) and linear mixed models (question 3) were conducted with adjustments for multiple comparisons.
Participants meeting diagnostic criteria for ADHD (62%) had greater pretreatment anxiety severity and anxiety-related functional impairment, particularly at school. ADHD did not moderate anxiety response following CBT. Receiving CBT (standard or adapted) predicted reduction in evaluator-rated ADHD severity, but not parent-reported symptoms. Reduction in anxiety severity predicted reduction in ADHD symptoms and severity.
Existing CBT programmes are suitable for treating anxiety in autistic children with cooccurring ADHD. Future research should identify mechanisms through which CBT for anxiety also mitigates ADHD, with the aim of improving treatment precision and effectiveness.
儿童心理健康状况通常会同时出现,这可能对治疗产生影响。自闭症儿童经常伴有焦虑症和注意力缺陷多动障碍(ADHD)。我们研究了这种共病情况对认知行为疗法(CBT)的影响,CBT是治疗自闭症儿童焦虑症的一线疗法。我们测试了:(1)ADHD是否能预测焦虑症治疗反应;(2)ADHD症状在焦虑症治疗后是否有所改善;(3)ADHD的改善是否与焦虑症减轻有关。
167名焦虑水平较高的自闭症儿童参与了一项多中心随机对照试验,该试验比较了标准CBT、自闭症适应性CBT和常规治疗。分别通过家长报告问卷和临床访谈评估ADHD症状及严重程度。采用线性回归(问题1和2)以及线性混合模型(问题3)进行分析,并对多重比较进行了校正。
符合ADHD诊断标准的参与者(62%)在治疗前焦虑严重程度和与焦虑相关的功能损害更大,尤其是在学校方面。ADHD并没有调节CBT后的焦虑反应。接受CBT(标准或适应性)可预测评估者评定的ADHD严重程度降低,但家长报告的症状没有改善。焦虑严重程度的降低可预测ADHD症状及严重程度的降低。
现有的CBT方案适用于治疗同时患有ADHD的自闭症儿童的焦虑症。未来的研究应确定CBT治疗焦虑症时减轻ADHD症状的机制,以提高治疗的精准度和有效性。