Rowland Payne C M, Wilkinson J D, McKee P H, Jurecka W, Black M M
Br J Dermatol. 1985 Oct;113(4):431-9. doi: 10.1111/j.1365-2133.1985.tb02357.x.
In a study of 46 patients with nodular prurigo (NP), potential metabolic causes of pruritus, such as anaemia, hepatic dysfunction, uraemia and myxoedema, were present in 50%. Focal causes of pruritus were important in 37% and included insect bites, venous stasis, folliculitis and nummular eczema. Psycho-social disorders were recorded in over 50% of patients and were considered relevant in 33%. Clinical and histological appearances ranged from classical NP to chronic lichenified eczema. Neural hyperplasia was not a prominent feature.
在一项针对46例结节性痒疹（NP）患者的研究中，50%的患者存在瘙痒的潜在代谢原因，如贫血、肝功能不全、尿毒症和黏液性水肿。37%的患者瘙痒的局部原因很重要，包括昆虫叮咬、静脉淤滞、毛囊炎和钱币状湿疹。超过50%的患者记录有心理社会障碍，其中33%被认为与之相关。临床和组织学表现从典型的NP到慢性苔藓化湿疹不等。神经增生不是突出特征。
