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一个肉质谜团:结节性痒疹。

A Fleshy Mystery: Prurigo Nodularis.

作者信息

Bona Jianna, Pippin Micah, Atkins Logan, Al-Quraishi Majeed

机构信息

Family Medicine, Louisiana State University (LSU) Health Shreveport/Rapides Regional Medical Center, Alexandria, USA.

Pathology, Louisiana State University (LSU) Health Shreveport/Rapides Regional Medical Center, Alexandria, USA.

出版信息

Cureus. 2024 Jul 22;16(7):e65125. doi: 10.7759/cureus.65125. eCollection 2024 Jul.

DOI:10.7759/cureus.65125
PMID:39171012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11338647/
Abstract

Prurigo nodularis is a chronic dermatologic condition typically presenting as firm, dome-shaped pruritic nodules of various sizes that are often symmetrically distributed on extensor surfaces of the extremities. The diagnosis is clinical and based on a history of chronic, severe pruritis in the setting of characteristic, excoriated lesions. Treatment is difficult and aimed at reducing skin irritation and pruritus. Quality of life is impacted due to the chronic, intractable, and relapsing nature of the disease. Here, we report a case of prurigo nodularis diagnosed in the outpatient clinic setting. This paper aims to report the patient's clinical history, presentation, and histopathologic findings, as well as present a literature review to determine the significance of this case and the approach to ongoing management.

摘要

结节性痒疹是一种慢性皮肤病,通常表现为大小不一、质地坚硬、呈圆顶状的瘙痒性结节,常对称分布于四肢伸侧。诊断基于临床症状,即在特征性抓痕性皮损背景下有慢性、严重瘙痒的病史。治疗困难,旨在减轻皮肤刺激和瘙痒。由于该病具有慢性、难治性和复发性,生活质量受到影响。在此,我们报告一例在门诊诊断的结节性痒疹病例。本文旨在报告患者的临床病史、表现和组织病理学发现,并进行文献综述以确定该病例的意义及持续管理方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2b/11338647/4b1064f04bf4/cureus-0016-00000065125-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2b/11338647/7db18b8f5c16/cureus-0016-00000065125-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2b/11338647/4b1064f04bf4/cureus-0016-00000065125-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2b/11338647/7db18b8f5c16/cureus-0016-00000065125-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2b/11338647/4b1064f04bf4/cureus-0016-00000065125-i02.jpg

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1
A Fleshy Mystery: Prurigo Nodularis.一个肉质谜团:结节性痒疹。
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本文引用的文献

1
Prurigo nodularis: Pathogenesis and management.结节性痒疹:发病机制与治疗。
J Am Acad Dermatol. 2020 Dec;83(6):1567-1575. doi: 10.1016/j.jaad.2020.04.182. Epub 2020 May 24.
2
Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis.结节性痒疹患者的诊断检查与评估
Medicines (Basel). 2019 Sep 26;6(4):97. doi: 10.3390/medicines6040097.
3
Real-World Prevalence of Prurigo Nodularis and Burden of Associated Diseases.结节性痒疹的真实世界患病率及相关疾病负担
J Invest Dermatol. 2020 Feb;140(2):480-483.e4. doi: 10.1016/j.jid.2019.07.697. Epub 2019 Aug 15.
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Diagnostic and treatment algorithm for chronic nodular prurigo.慢性结节性痒疹的诊断和治疗方案。
J Am Acad Dermatol. 2020 Feb;82(2):460-468. doi: 10.1016/j.jaad.2019.07.022. Epub 2019 Jul 13.
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Dupilumab Treatment for Generalized Prurigo Nodularis.度普利尤单抗治疗泛发性结节性痒疹。
JAMA Dermatol. 2019 Jan 1;155(1):118-120. doi: 10.1001/jamadermatol.2018.3912.
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A systematic review of evidence-based treatments for prurigo nodularis.结节性痒疹的循证治疗系统评价。
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The pathogenesis of Prurigo nodularis--'Super-Itch' in exploration.结节性痒疹的发病机制——探索“超级瘙痒”
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Nuclear localization of activated STAT6 and STAT3 in epidermis of prurigo nodularis.结节性痒疹表皮中活化的 STAT6 和 STAT3 的核定位。
Br J Dermatol. 2011 Nov;165(5):990-6. doi: 10.1111/j.1365-2133.2011.10498.x. Epub 2011 Sep 29.
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An occlusive dressing containing betamethasone valerate 0.1% for the treatment of prurigo nodularis.一种含有 0.1%倍他米松戊酸酯的闭塞性敷料,用于治疗结节性痒疹。
J Dermatolog Treat. 2010 Nov;21(6):363-6. doi: 10.3109/09546630903386606.
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Narrow-band ultraviolet B phototherapy in patients with recalcitrant nodular prurigo.窄谱中波紫外线光疗治疗顽固性结节性痒疹患者。
J Dermatol. 2007 Oct;34(10):691-5. doi: 10.1111/j.1346-8138.2007.00360.x.