Wu Qilong, Li Xufeng, Lv Jian, Shi Yongjia, Yang Daoshan
College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, P. R. China.
Zhejiang Wansheng Co., Ltd., Linhai, Zhejiang 317000, P. R. China.
Org Lett. 2025 Jul 18;27(28):7703-7708. doi: 10.1021/acs.orglett.5c02449. Epub 2025 Jul 9.
A copper/photoredox dual-catalysis-enabled 1,4-arylcyanation of 1,3-enynes to afford tetrasubstituted allenyl nitriles was initially developed. The reaction features good reaction generality and high reaction regioselectivity, providing facile access to multifunctionalized allenyl nitriles. This strategy achieves the construction of aryl-containing tetrasubstituted allenyl nitriles via indirect arene C-H functionalization. It also serves as an important complement to thianthrenium salt chemistry.
最初开发了一种铜/光氧化还原双催化的1,3-烯炔1,4-芳基氰化反应，以得到四取代的丙二烯腈。该反应具有良好的反应通用性和高反应区域选择性，为多官能化丙二烯腈的合成提供了便捷途径。该策略通过间接的芳烃C-H官能化实现了含芳基的四取代丙二烯腈的构建。它也是噻蒽鎓盐化学的重要补充。
