Yang Chengxiao, Biswal Bharat B, Wang Pan
MOE Key Laboratory for Neuroinformatics, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Brain Struct Funct. 2025 Jul 9;230(6):116. doi: 10.1007/s00429-025-02962-0.
Functional connectivity (FC) is a key tool for understanding the complex interactions within the human brain, highlighting connections between various regions. This study delves into the multifaceted influences shaping functional magnetic resonance imaging FC patterns during movie watching, focusing on the effects of sex, age, and movie clip. Leveraging the Human Connectome Project dataset, we systematically examine FC patterns elicited during movie watching. Notably, sex-specific variations in FC are observed, with females exhibiting heightened FC within visual, limbic, and default mode networks, while males display predominant intra-network connectivity within somatomotor and attention networks. Age-related variations further manifest, revealing FC increases with age in early adulthood (21-35 years old) within some specific networks. Moreover, our investigation unveils the profound influence of movie clips on FC patterns, with significant interactions observed between clips, sex, and age. Feature selection using the Average Cross-Session Correlation method highlights FC as distinct fingerprints of clips, and the Support Vector Machine classifier shows high accuracy (Accuracy > 0.9) when using these features. Our findings underscore the importance of considering individual demographic factors and external stimuli in understanding neural connectivity dynamics during movie-watching, with implications for both basic neuroscience research and clinical neuroimaging applications.
功能连接（FC）是理解人类大脑内复杂相互作用的关键工具，突出了不同区域之间的联系。本研究深入探讨了在观看电影期间塑造功能磁共振成像FC模式的多方面影响，重点关注性别、年龄和电影片段的影响。利用人类连接组计划数据集，我们系统地检查了观看电影期间引发的FC模式。值得注意的是，观察到FC存在性别特异性差异，女性在视觉、边缘和默认模式网络中表现出更高的FC，而男性在躯体运动和注意力网络中表现出主要的网络内连接。与年龄相关的差异进一步显现，揭示了在成年早期（21 - 35岁）某些特定网络中FC随年龄增长而增加。此外，我们的研究揭示了电影片段对FC模式的深远影响，在片段、性别和年龄之间观察到显著的相互作用。使用平均跨会话相关性方法进行特征选择突出了FC作为片段的独特指纹，并且支持向量机分类器在使用这些特征时显示出高精度（准确率> 0.9）。我们的研究结果强调了在理解观看电影期间的神经连接动态时考虑个体人口统计学因素和外部刺激的重要性，这对基础神经科学研究和临床神经成像应用都有影响。
