Schuurman Levi J M, Sobczak Sjacko, Schulkens Julie E M, Balter Benno P F, van Alphen Sebastiaan P J
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience (FPN), Maastricht University, Maastricht, the Netherlands.
Clinical Center of Excellence for Older Adults with Personality Disorders, Mondriaan, Mental Health Center, Heerlen, Maastricht, the Netherlands.
Hum Psychopharmacol. 2025 Jul;40(4):e70009. doi: 10.1002/hup.70009.
Patient-reported side-effect questionnaires contribute to balanced decisions regarding treatment strategy among patients with mental health disorders. However, current side-effect questionnaires are less suitable for older adults because they often lack age-specific side effects. Therefore, the Scale for Subjective Somatic and Cognitive Complaints of Psychotropic Medication Adult-Aged-Spectrum (SCOPA) was developed to quantify psychotropic side effects across the full adult age spectrum. The aim of this study was to develop and evaluate the reliability and validity of the SCOPA.
Psychometric properties of the SCOPA were assessed in a Dutch patient population (n = 205, age 18-86 years) and a general population (n = 281, age 18-87 years). Reliability of the subscales was measured through average inter-item correlation and Cronbach's alphas. Construct validity was analysed by exploratory factor analysis.
Average inter-item correlation and Cronbach's alphas of the subscales of the SCOPA were moderate to good. Exploratory factor analyses supported a two-factor solution, labelled as complaints in somatic and cognitive domains.
This study showed that the SCOPA has promising psychometric qualities and practical capability to evaluate the side-effect burden of treatment with psychotropic medication across the adult-aged-spectrum. However, more research is needed to cross-validate these results in the field's pursuit of increased patient safety.
患者报告的副作用问卷有助于精神健康障碍患者在治疗策略上做出平衡的决策。然而，目前的副作用问卷不太适合老年人，因为它们往往缺乏针对特定年龄段的副作用。因此，开发了成人年龄谱精神药物主观躯体和认知投诉量表（SCOPA），以量化整个成人年龄谱的精神药物副作用。本研究的目的是开发和评估SCOPA的信度和效度。
在荷兰患者群体（n = 205，年龄18 - 86岁）和普通人群（n = 281，年龄18 - 87岁）中评估SCOPA的心理测量特性。通过平均项目间相关性和克朗巴哈系数测量分量表的信度。通过探索性因素分析来分析结构效度。
SCOPA分量表的平均项目间相关性和克朗巴哈系数为中等至良好。探索性因素分析支持两因素解决方案，标记为躯体和认知领域的投诉。
本研究表明，SCOPA在评估整个成人年龄谱精神药物治疗的副作用负担方面具有良好的心理测量质量和实际应用能力。然而，在该领域为提高患者安全性而进行交叉验证这些结果还需要更多研究。
