He Ping, Hu Fangqi, Wang Fei
Department of Pediatrics, Anqing Municipal Hospital, Anqing, Anhui, China.
PLoS One. 2025 Jul 9;20(7):e0326369. doi: 10.1371/journal.pone.0326369. eCollection 2025.
To explore the relationship between respiratory viral infections complicated by cough and wheezing and the clinical features of thrombocythemia in infants.
We retrospectively analyzed the clinical data of 200 infants with fever, cough and wheezing who were admitted to the Department of Pediatrics of Anqing Municipal Hospital between January 2023 and October 2024. Respiratory viruses were detected using real-time PCR to screen for virus-positive infants. Infants were classified into the thrombocythemia group (ST group) and the non-thrombocythemia group (non-ST group) based on platelet counts. We compared the clinical characteristics of the two groups and analyzed the relationships between thrombocythemia, positive respiratory virus results, and cough with wheezing.
The overall virus positivity detection rate was 56.5% (113/200). In the ST group, patients with positive respiratory virus results had significantly longer hospital stays, higher fever incidence, and more severe cough symptoms (P < 0.05), and significantly higher leukocyte and interleukin-6 (IL-6) levels (P < 0.05). Among the virus-positive cases, the duration of fever, cough, and wheezing was longer in the ST group than in the non-ST group (P < 0.05). Higher platelet counts were significantly associated with longer hospitalization duration, prolonged cough duration and a higher co-occurring wheezing rate (p < 0.05). Point-biserial correlation analysis indicated that thrombocythemia was closely associated with respiratory virus positivity complicated by cough and wheeze (r = 0.314, P < 0.05). Multifactorial analysis revealed that age, non-respiratory symptoms, platelet levels, and IL-6 level were independent influencing factors for respiratory virus-positive infants with complicated cough and wheezing (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the areas under the curve of thrombocythemia for assessing hospital stay duration and cough and wheeze durations were 0.964 and 0.936, respectively (P < 0.05), indicating a significant assessment value.
Infant respiratory viral infections complicated by cough and wheezing are closely related to secondary thrombocythemia. Elevated platelet levels can prolong the hospital stay and cough duration. The clinical risk in children can be assessed early by measuring platelet levels.
探讨婴儿呼吸道病毒感染合并咳嗽和喘息与血小板增多症临床特征之间的关系。
回顾性分析2023年1月至2024年10月期间安庆市立医院儿科收治的200例发热、咳嗽和喘息婴儿的临床资料。采用实时荧光定量PCR检测呼吸道病毒，筛选出病毒阳性婴儿。根据血小板计数将婴儿分为血小板增多症组（ST组）和非血小板增多症组（非ST组）。比较两组的临床特征，并分析血小板增多症、呼吸道病毒检测阳性结果与咳嗽伴喘息之间的关系。
总体病毒阳性检出率为56.5%（113/200）。在ST组中，呼吸道病毒检测阳性的患者住院时间显著延长、发热发生率更高、咳嗽症状更严重（P<0.05），白细胞和白细胞介素-6（IL-6）水平也显著更高（P<0.05）。在病毒阳性病例中，ST组的发热、咳嗽和喘息持续时间比非ST组更长（P<0.05）。较高的血小板计数与更长的住院时间、更长的咳嗽持续时间和更高的喘息并发率显著相关（P<0.05）。点二列相关分析表明，血小板增多症与呼吸道病毒阳性合并咳嗽和喘息密切相关（r=0.314，P<0.05）。多因素分析显示，年龄、非呼吸道症状、血小板水平和IL-6水平是呼吸道病毒阳性合并咳嗽和喘息婴儿的独立影响因素（P<0.05）。受试者工作特征（ROC）曲线分析显示，血小板增多症用于评估住院时间和咳嗽及喘息持续时间的曲线下面积分别为0.964和0.936（P<0.05），表明具有显著的评估价值。
婴儿呼吸道病毒感染合并咳嗽和喘息与继发性血小板增多症密切相关。血小板水平升高可延长住院时间和咳嗽持续时间。通过检测血小板水平可早期评估儿童的临床风险。
