Liberty Jacob T, Lin Haijiao, Sipos Yona, Ihedioha Olivia C, Kwaji Magdaline J
FEEH Innovations, 38 Maple Street, Ste-Anne-de-Bellevue, Montreal, Quebec H9X 2E6, Canada.
Department of Animal Science, McGill University, Sainte-Anne-de-Bellevue, Montreal, Quebec H9X 3V9, Canada.
Curr Opin Biotechnol. 2025 Aug;94:103334. doi: 10.1016/j.copbio.2025.103334. Epub 2025 Jul 8.
The intersection of gene editing and cellular agriculture is transforming food production by offering sustainable, ethical alternatives to conventional agriculture. Cellular agriculture uses tissue engineering and fermentation technologies to produce animal-free food, whereas gene editing tools like CRISPR-Cas9 optimize cellular efficiency, nutritional value, and sustainability. While some researchers emphasize the environmental and food security benefits, others raise concerns about high costs, regulatory challenges, and consumer acceptance. This paper critically examines existing literature, compares breakthroughs and controversies, and provides an expert perspective on the challenges and opportunities in gene-edited cellular agriculture. By tackling key scientific, economic, regulatory, and ethical issues, this article presents a roadmap for responsibly advancing these technologies and integrating them into global food systems. To our knowledge, this is the first work to explore how gene editing and cellular agriculture can be synergized to advance sustainability, food security, and global health.
基因编辑与细胞农业的交叉融合正在改变粮食生产方式，为传统农业提供可持续、符合伦理道德的替代方案。细胞农业利用组织工程和发酵技术生产无动物源食品，而像CRISPR-Cas9这样的基因编辑工具则可优化细胞效率、营养价值和可持续性。尽管一些研究人员强调其对环境和粮食安全的益处，但另一些人则对高成本、监管挑战以及消费者接受度表示担忧。本文批判性地审视了现有文献，比较了各项突破与争议，并就基因编辑细胞农业面临的挑战与机遇提供了专家观点。通过解决关键的科学、经济、监管和伦理问题，本文提出了一条负责任地推进这些技术并将其融入全球粮食系统的路线图。据我们所知，这是第一项探索基因编辑与细胞农业如何协同作用以促进可持续性、粮食安全和全球健康的研究。
