Cold exposure or chronic noradrenaline treatment induces an increase in the calmodulin-like immunoreactivity of brown adipose tissue of rats.

Cell proliferation is often associated with an increase in calmodulin, the ubiquitous intracellular calcium receptor of non-muscle cells. A long lasting increase in the proliferative activity of brown adipose tissue is induced by cold exposure in the rat. The present work showed that this phenomenon is also associated with a rapid and long lasting increase in the calmodulin content of this tissue. It was equally shown that this increase can be reproduced by noradrenaline administration.