棕色脂肪组织在冷适应大鼠中对肾上腺素和去甲肾上腺素产热效应的作用。
The role of brown adipose tissue in the calorigenic effect of adrenaline and noradrenaline in cold-acclimated rats.
作者信息
Himms-Hagen J
出版信息
J Physiol. 1969 Nov;205(2):393-403. doi: 10.1113/jphysiol.1969.sp008973.
Abstract
- Removal of the interscapular brown adipose tissue of the cold-acclimated rat has no immediate effect on the calorigenic response of the rat to adrenaline or noradrenaline.2. There is a progressive loss of the enhanced response to adrenaline and to noradrenaline during the 4 days following removal of the interscapular brown adipose tissue from cold-acclimated rats. There is no loss of response in sham-operated cold-acclimated rats.3. Removal of the interscapular brown adipose tissue from rats living at room temperature has no effect on the calorigenic response to adrenaline or noradrenaline, neither immediately afterwards nor 2-4 days later.4. It is concluded that interscapular brown adipose tissue is not the major site of oxygen consumption in the enhanced calorigenic response to adrenaline or noradrenaline in cold-acclimated rats. However, it does play an important role in this enhanced metabolic response, probably as an endocrine gland whose secretory product modifies the ability of other tissues to respond calorigenically to catecholamines.
摘要
切除冷适应大鼠的肩胛间棕色脂肪组织，对大鼠对肾上腺素或去甲肾上腺素的产热反应没有立即影响。
从冷适应大鼠切除肩胛间棕色脂肪组织后的4天内，对肾上腺素和去甲肾上腺素的增强反应逐渐丧失。假手术的冷适应大鼠没有反应丧失。
从室温环境下的大鼠切除肩胛间棕色脂肪组织，对肾上腺素或去甲肾上腺素的产热反应没有影响，术后即刻及2 - 4天后均无影响。
得出结论：肩胛间棕色脂肪组织不是冷适应大鼠对肾上腺素或去甲肾上腺素增强产热反应中耗氧的主要部位。然而，它在这种增强的代谢反应中确实起重要作用，可能作为一种内分泌腺，其分泌产物改变其他组织对儿茶酚胺产热反应的能力。
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