Khmel'-Dunaĭ G N, Narushiavichus E V
Biull Eksp Biol Med. 1985 Nov;100(11):559-61.
Dependence of calcium ion efflux from the heart ventricles on the concentration of verapamil, fenigidine and nicardipine was studied in frogs, using Ca-sensitive electrodes. The effect of sodium and potassium ions was also investigated. It was established that dependence of calcium ion efflux (delta Ca2+) on the concentration of Ca-antagonists (B) may be expressed by the following formula: (Formula: see text). With cellular membrane depolarization 50 mM KCl, none of the blockers (10(-5) M) caused Ca2+ efflux from ventricular cells. Analogous phenomenon was noted in low-sodium solution (60 mM).
使用钙敏感电极，在青蛙身上研究了心室中钙离子流出对维拉帕米、非尼地平以及尼卡地平浓度的依赖性。同时也研究了钠和钾离子的作用。结果表明，钙离子流出量（δCa2+）对钙拮抗剂（B）浓度的依赖性可用以下公式表示：（公式：见原文）。当细胞膜用50 mM KCl去极化时，所有阻滞剂（10(-5) M）都不会导致心室细胞中的Ca2+流出。在低钠溶液（60 mM）中也观察到了类似现象。
