[Effect of the calcium antagonists ryodipine and verapamil on the carnitine-dependent metabolism of fatty acids in the rat heart].

Riodipine (10 days, 10 mg/kg) was shown to prevent in rats an isoproterenol-induced increase of free fatty acid concentration in the blood serum and heart and to promote normalization of long-chain acylcarnitine content in the heart. Under the same conditions verapamil caused an increase in free acid concentration in the blood serum and prevented their accumulation in the heart. Its ability to limit accumulation of long-chain acylcarnitine manifested itself in a lesser degree as compared to riodipine. Riodipine exerted no effect on oxidation of 1-14-C-palmitic acid by the rat heart homogenate, verapamil suppressed oxidation of this fatty acid.