Takahashi Jun, Kikuchi Kota, Inano Rui, Kawamata Yasushi, Sugawara Norio, Yasui-Furukori Norio
Department of Psychiatry, School of Medicine, Dokkyo Medical University, Shimotsuga, Tochigi, Japan.
Neuropsychopharmacol Rep. 2025 Sep;45(3):e70037. doi: 10.1002/npr2.70037.
A 50-year-old woman with schizophrenia overdosed on risperidone, lormetazepam, and lorazepam and subsequently developed rhabdomyolysis, with elevated creatine kinase (CK) and myoglobin levels. Intravenous treatment stabilized her condition. Risperidone was restarted at a regular dose, and rhabdomyolysis did not recur. She was discharged after 29 days, and she continued outpatient care without further complications. There have been no reports of rhabdomyolysis caused by overdosing on risperidone alone. This case is important for understanding the risk profile of this drug.
一名50岁的精神分裂症女性过量服用利培酮、氯美扎酮和劳拉西泮,随后出现横纹肌溶解,肌酸激酶(CK)和肌红蛋白水平升高。静脉治疗使她的病情稳定。利培酮以常规剂量重新开始服用,横纹肌溶解未复发。29天后她出院,继续接受门诊护理,没有出现进一步并发症。尚无单独过量服用利培酮导致横纹肌溶解的报告。该病例对于了解这种药物的风险状况很重要。