Tarčuković Janja, Klarica Lucia, Dugonjić Mario, Vuksan Ivan, Pavlešić Tomislav, Šonjić Pavica, Bilić-Zulle Lidija, Župčić Miroslav, Šustić Alan, Zelić Marko
Janja Tarčuković, University of Rijeka, Faculty of Medicine, Department of Anesthesiology, Resuscitation, Emergency and Intensive Care Medicine, Tome Strižića 3, 51000 Rijeka, Croatia,
Croat Med J. 2025 Jul 5;66(3):204-212.
To compare the effects of an in-house prepared honey solution (HS) and a commercial carbohydrate beverage (CCB) on postoperative stress response, gastric motility, and self-reported comfort in patients undergoing laparoscopic cholecystectomy.
This randomized controlled trial enrolled 55 adult patients (the American Society of Anesthesiologists physical status I-II) undergoing laparoscopic cholecystectomy at the University Hospital Center Rijeka from January 1, 2022, to December 31, 2022. Participants were randomly assigned to receive either HS (n=20), prepared from diluted chestnut honey, or CCB (n=35). Both solutions were administered in the volumes of 800 mL the evening before surgery and 400 mL two hours before anesthesia. Stress response and inflammation were assessed by measuring cortisol and interleukin 6 levels at six standardized time points. Gastric motility was evaluated with a paracetamol absorption test, and patient-reported outcomes were recorded postoperatively using a visual analogue scale.
The HS group exhibited higher cortisol and interleukin 6 levels at multiple perioperative time points compared with the CCB group (P<0.05). However, they had significantly improved gastric motility, with higher paracetamol concentrations 15 to 180 minutes post-ingestion (P=0.028-0.001). Additionally, HS group reported reduced thirst, nausea, and pain, but had lower appetite and well-being scores.
While HS represents a potential natural and cost-effective alternative to CCB, further studies are needed to determine its role within preoperative nutrition strategies for enhanced recovery after surgery.
比较自制蜂蜜溶液（HS）和市售碳水化合物饮料（CCB）对接受腹腔镜胆囊切除术患者术后应激反应、胃动力及自我报告舒适度的影响。
本随机对照试验纳入了2022年1月1日至2022年12月31日在里耶卡大学医院中心接受腹腔镜胆囊切除术的55例成年患者（美国麻醉医师协会身体状况分级为I-II级）。参与者被随机分配接受由稀释的栗树蜂蜜制成的HS（n = 20）或CCB（n = 35）。两种溶液均在手术前一晚给予800 mL，麻醉前两小时给予400 mL。通过在六个标准化时间点测量皮质醇和白细胞介素6水平来评估应激反应和炎症。通过对乙酰氨基酚吸收试验评估胃动力，并在术后使用视觉模拟量表记录患者报告的结果。
与CCB组相比，HS组在多个围手术期时间点的皮质醇和白细胞介素6水平更高（P<0.05）。然而，他们的胃动力有显著改善，摄入后15至180分钟时对乙酰氨基酚浓度更高（P = 0.028 - 0.001）。此外，HS组报告口渴、恶心和疼痛减轻，但食欲和幸福感得分较低。
虽然HS是CCB一种潜在的天然且经济高效的替代品，但需要进一步研究以确定其在术前营养策略中对促进术后恢复的作用。
