Lee Gyumin, Suh Jeong Yoon, Kim Junyeol, Park Tae Young, Do Jae Hyuk, Choi Yoo Shin, Lee Seung Eun, Lee Tae Yoon, Kang Hyun, Oh Hyoung-Chul
Department of Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
Korean J Intern Med. 2025 Jul;40(4):584-591. doi: 10.3904/kjim.2025.090. Epub 2025 Jun 30.
BACKGROUND/AIMS: The incidence of cholesterol gallstones has increased in the last few decades. This study aimed to evaluate the prevalence of cholesterol gallstones in Korea over a 14-year period, analyze any changes, and identify the predisposing factors.
A total of 3,909 patients underwent cholecystectomy for gallstones over the 14-year period and were considered for inclusion in this study. Patients were divided into cholesterol and pigment gallstone groups based on gallstone composition, as determined by Fourier Transform Infrared spectroscopy. Patient characteristics were compared between the two groups.
After the exclusion of 259 patients with mixed type gallstones, 3,650 patients were finally included in this study; 2,038 (55.8%) with cholesterol gallstones and 1,612 (44.2%) with pigment gallstones. The proportion of cholesterol gallstones over the 14-year period was 53.8% of the study population as a whole and 77.5% of individuals aged < 50 years. The multivariate analysis revealed that cholesterol gallstones were associated with an age < 50 years, female sex, central obesity, absence of chronic liver diseases, and diabetes mellitus. High density lipoprotein-cholesterol levels showed a tendency toward an association with cholesterol gallstones.
The prevalence of cholesterol gallstones in Korea plateaued 53.8% during the 14-year period. However, given the increasing incidence of cholesterol gallstones among younger individuals, the relative prevalence of cholesterol gallstones may increase in the future.
背景/目的：在过去几十年中，胆固醇结石的发病率有所上升。本研究旨在评估韩国14年间胆固醇结石的患病率，分析其变化情况，并确定易感因素。
在14年期间，共有3909例因胆结石接受胆囊切除术的患者被纳入本研究。根据傅里叶变换红外光谱法测定的胆结石成分，将患者分为胆固醇结石组和色素结石组。比较两组患者的特征。
排除259例混合型胆结石患者后，最终有3650例患者纳入本研究；其中胆固醇结石患者2038例（55.8%），色素结石患者1612例（44.2%）。在14年期间，胆固醇结石患者占研究总体人群的53.8%，在年龄<50岁的个体中占77.5%。多因素分析显示，胆固醇结石与年龄<50岁、女性、中心性肥胖、无慢性肝病和糖尿病有关。高密度脂蛋白胆固醇水平显示出与胆固醇结石有关的趋势。
韩国胆固醇结石的患病率在14年期间稳定在53.8%。然而，鉴于年轻个体中胆固醇结石的发病率不断上升，未来胆固醇结石的相对患病率可能会增加。
