Li Hongliang, Zhang Congfeng
Department of General Surgery, Dandong Central Hospital, Dandong, China.
Department of Intensive Care Unit, Dandong Central Hospital, Dandong, China.
Sci Rep. 2024 Aug 1;14(1):17778. doi: 10.1038/s41598-024-68841-6.
This study used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the relationship between the triglyceride-glucose (TyG) index and gallstones. We evaluated the data collected between 2017 to 2020. To evaluate the relationship between TyG index and gallstones, logistic regression analysis, basic characteristics of participants, subgroup analysis, and smooth curve fitting were utilized. The study included 3870 participants over the age of 20 years, 403 of whom reported gallstones, with a prevalence rate of 10.4%. After adjusting for all confounding factors, the risk of gallstones increased by 41% for each unit increase in the TyG index (OR 1.41, 95% CI 1.07, 1.86). The smooth curve fitting also showed a positive correlation between the TyG index and gallstones. Subgroup analysis revealed a significant positive relationship between the TyG index and the risk of gallstones in those aged < 50 years, women, individuals with total cholesterol levels > 200 mg/dL, individuals with body mass index (BMI) > 25, and individuals without diabetes. The risk of gallstones is positively correlated with a higher TyG index. Thus, the TyG index can be used as a predictor of the risk of gallstones.
本研究使用了来自美国国家健康与营养检查调查（NHANES）的数据，以调查甘油三酯-葡萄糖（TyG）指数与胆结石之间的关系。我们评估了2017年至2020年期间收集的数据。为了评估TyG指数与胆结石之间的关系，我们采用了逻辑回归分析、参与者的基本特征分析、亚组分析和平滑曲线拟合。该研究纳入了3870名20岁以上的参与者，其中403人报告患有胆结石，患病率为10.4%。在对所有混杂因素进行调整后，TyG指数每增加一个单位，胆结石的风险增加41%（比值比1.41，95%置信区间1.07，1.86）。平滑曲线拟合也显示TyG指数与胆结石之间呈正相关。亚组分析显示，在年龄<50岁的人群、女性、总胆固醇水平>200mg/dL的个体、体重指数（BMI）>25的个体以及无糖尿病的个体中，TyG指数与胆结石风险之间存在显著的正相关关系。胆结石风险与较高的TyG指数呈正相关。因此，TyG指数可作为胆结石风险的预测指标。
