Donoso A O
Braz J Med Biol Res. 1985;18(1):97-100.
The possible participation of GABA (gamma-aminobutyric acid) in the enhanced release of luteinizing hormone that follows orchidectomy was examined. The GABA-transaminase inhibitor, gamma vinyl GABA, injected stereotaxically into the locus ceruleus area blocked the postcastration rise of luteinizing hormone in plasma. In contrast, this response developed normally when the drug was administered either to the medial or the dorsal preoptic area and to the mediobasal hypothalamus. The present preliminary results suggest that the increase of GABA at synaptic sites affects luteinizing hormone release in castrated male rats through an action on the noradrenergic cell bodies of the locus ceruleus system.
研究了γ-氨基丁酸（GABA）是否可能参与睾丸切除术后促黄体生成素释放增强的过程。将GABA转氨酶抑制剂γ-乙烯基GABA立体定向注射到蓝斑区域，可阻断去势后血浆中促黄体生成素的升高。相比之下，当将该药物注射到内侧或背侧视前区以及下丘脑中间基底部时，这种反应正常出现。目前的初步结果表明，突触部位GABA的增加通过作用于蓝斑系统的去甲肾上腺素能细胞体，影响去势雄性大鼠促黄体生成素的释放。
