Yan Jian-Hua, Liang Chun-Xiao, Ma Ran-Ran, Li Bo-Jia, Chen Qi-Wen, Li Wen, Zeng Xuan, Zhang Xian-Zheng
Key Laboratory of Biomedical Polymers of Ministry of Education, & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Adv Healthc Mater. 2024 Dec 8:e2403738. doi: 10.1002/adhm.202403738.
Inflammatory bowel disease (IBD) is associated with elevated levels of reactive oxygen species (ROS) and an increased expression of proinflammatory cytokines. Anti-inflammatory drugs, monoclonal antibodies, and immunomodulators are commonly employed to control the inflammatory response in the management of IBD. Here, a copper and tannic acid (TA) coordination nanozyme (CuTA) loaded with sulfasalazine (SSZ-CuTA) is synthesized for the treatment of IBD by simultaneous scavenging ROS and immunosuppression. The CuTA exhibits both dismutase-like activity and catalase-like activity, making it efficient at scavenging ROS. These nanozymes can efficiently traverse gastric acid and subsequently exert their effects within the intestinal tract. It is verified that SSZ-CuTA can restore intestinal mucosal and goblet cells to a healthy state by effectively eliminating ROS and reducing the pro-inflammatory factors in a mouse IBD model. Overall, the SSZ-CuTA will offer a promising alternative treatment for patients suffering from IBD where excessive ROS and high inflammation coexist.
炎症性肠病（IBD）与活性氧（ROS）水平升高和促炎细胞因子表达增加有关。在IBD的治疗中，通常使用抗炎药物、单克隆抗体和免疫调节剂来控制炎症反应。在此，合成了一种负载柳氮磺胺吡啶（SSZ-CuTA）的铜与单宁酸（TA）配位纳米酶（CuTA），通过同时清除ROS和免疫抑制来治疗IBD。CuTA具有超氧化物歧化酶样活性和过氧化氢酶样活性，使其能够高效清除ROS。这些纳米酶能够有效穿越胃酸，随后在肠道内发挥作用。在小鼠IBD模型中证实，SSZ-CuTA可通过有效清除ROS和减少促炎因子，使肠道黏膜和杯状细胞恢复到健康状态。总体而言，对于ROS过多和炎症程度高并存的IBD患者，SSZ-CuTA将提供一种有前景的替代治疗方法。
