Attout Hassene, Constant Jade, Abdellatif Amal, Barry Guillaume, Halle Olivier
Internal Medicine Department, Les Cevennes Hospital, Alès, France.
Eur J Case Rep Intern Med. 2025 Jun 5;12(7):005480. doi: 10.12890/2025_005480. eCollection 2025.
Thymus is a primary lymphoid organ whose main function is the education of the T lymphocytes. Thymoma is uncommon neoplasia derived from epithelial cells of the thymus. Patients with thymoma frequently present with autoimmune disorders, mostly myasthenia gravis. Good's syndrome (GS) is an acquired adult-onset combined immunodeficiency typically characterised by the triad of thymoma, hypogammaglobulinaemia and increased susceptibility to recurrent infections. Immunoglobulin replacement is the main therapeutic strategy. Our knowledge of thymoma-associated immunodeficiency is predominantly derived from case reports or small series. We report the case of a patient with recurrent sigmoid diverticulitis that appeared after a thymectomy, who was subsequently found to have severe hypogammaglobulinaemia.
Good's syndrome is a rare, acquired, adult-onset immunodeficiency.Good's syndrome remains an enigmatic disease.Immunoglobulin replacement is the main therapeutic strategy.
胸腺是主要的淋巴器官，其主要功能是对T淋巴细胞进行培育。胸腺瘤是一种源自胸腺上皮细胞的罕见肿瘤。胸腺瘤患者常伴有自身免疫性疾病，多数为重症肌无力。古德综合征（GS）是一种后天获得性成人发病的联合免疫缺陷病，其典型特征为胸腺瘤、低丙种球蛋白血症和反复感染易感性增加三联征。免疫球蛋白替代疗法是主要的治疗策略。我们对胸腺瘤相关免疫缺陷的认识主要来源于病例报告或小样本系列研究。我们报告了一例患者，其在胸腺切除术后出现复发性乙状结肠憩室炎，随后被发现患有严重的低丙种球蛋白血症。
古德综合征是一种罕见的、后天获得性成人发病的免疫缺陷病。古德综合征仍然是一种难以捉摸的疾病。免疫球蛋白替代疗法是主要的治疗策略。
