Nagahara Keiko, Motegi Sakura, Ochi Ayako, Toyoda Junya, Nakano Yuya, Imai Takanori, Adachi Masanori, Yamagishi Sho-Ichi, Mizuno Katsumi
Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University Graduate School of Medicine, Tokyo, Japan.
Clin Pediatr Endocrinol. 2025 Jul;34(3):162-171. doi: 10.1297/cpe.2024-0042. Epub 2025 May 24.
Advanced glycation end-products (AGEs) formed by non-enzymatic glycation reactions between sugars and proteins have been implicated in various age-related disorders. Skin autofluorescence (SAF) is a noninvasive method for estimating the accumulated AGEs levels in the human body. However, the SAF values in healthy children have not yet been reported. This study aimed to determine reference values and factors affecting SAF values in apparently healthy schoolchildren. The study included 426 children (aged 8.9 ± 1.7 yr), including 224 boys and 202 girls from one public elementary school. SAF values were measured using an AGE reader. Data on the perinatal history, eating and exercise habits, lifestyle, family background, and medical history of the participants and their family medical history were collected using a questionnaire. The mean SAF value of the participants was 1.06 ± 0.19 AU, lower than that of healthy adults, and did not increase with calendar age. Moreover, a family history of diabetes within second-degree relatives was the sole significant factor associated with SAF values (p = 0.045), and it exhibited no association with life environmental factors. In conclusion, genetically defined susceptibility to glycation may be the most important factor in AGE accumulation in schoolchildren.
糖与蛋白质之间通过非酶糖基化反应形成的晚期糖基化终产物（AGEs）与多种年龄相关疾病有关。皮肤自发荧光（SAF）是一种用于估计人体中AGEs积累水平的非侵入性方法。然而，尚未有关于健康儿童SAF值的报道。本研究旨在确定明显健康的学童的SAF参考值以及影响SAF值的因素。该研究纳入了426名儿童（年龄8.9±1.7岁），其中包括来自一所公立小学的224名男孩和202名女孩。使用AGE读数仪测量SAF值。通过问卷调查收集了参与者的围产期病史、饮食和运动习惯、生活方式、家庭背景以及病史及其家族病史。参与者的平均SAF值为1.06±0.19 AU，低于健康成年人，且不随日历年龄增加。此外，二级亲属中有糖尿病家族史是与SAF值相关的唯一显著因素（p = 0.045），并且它与生活环境因素无关联。总之，遗传定义的糖基化易感性可能是学童中AGE积累的最重要因素。
