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宫颈淋巴管平滑肌瘤:常见部位的罕见病因——病例报告及文献综述

Cervical Lymphangiolipoleiomyoma: An Unusual Offender at a Usual Destination - Case Report and Literature Review.

作者信息

Osama Md Ali, Gaur Kavita, Agarwal Kiran, Pandey Ankita, Yadav Reena

机构信息

Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Department of Pathology, Lady Hardinge Medical College, New Delhi, India.

出版信息

J Midlife Health. 2025 Apr-Jun;16(2):211-214. doi: 10.4103/jmh.jmh_4_25. Epub 2025 May 6.

DOI:10.4103/jmh.jmh_4_25
PMID:40636839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12237200/
Abstract

Cervical fibroids are relatively rare compared to fibroids that develop in other parts of the uterus, accounting for nearly 1%-2% of all fibroids. They typically originate from the supravaginal or vaginal portions of the cervix. One histological variant is angiolipoleiomyoma (ALLM), a benign mixed mesenchymal neoplasm composed of smooth muscle, mature adipose tissue, and abnormal blood vessels. While there are case reports of ALLM occurring in the kidneys, its presence in the female genital tract is extremely uncommon. Furthermore, here, we present a novel case of a 40-year-old postmenopausal female who presented with a long history of vaginal bleeding. Ultrasound revealed a fibroid located at the cervix; however, with histopathology revealing it to be a lymphangiolipoleiomyoma with a plethora of lymphatics. To the best of our knowledge, this is the first such case described in the medical literature.

摘要

与发生在子宫其他部位的肌瘤相比,宫颈肌瘤相对少见,约占所有肌瘤的1%-2%。它们通常起源于宫颈的阴道上段或阴道部。一种组织学变异型是血管脂肪瘤样平滑肌瘤(ALLM),这是一种由平滑肌、成熟脂肪组织和异常血管组成的良性混合性间叶肿瘤。虽然有ALLM发生于肾脏的病例报告,但其在女性生殖道中的存在极为罕见。此外,在此我们报告一例新病例,一名40岁绝经后女性,有长期阴道出血病史。超声检查发现宫颈有一个肌瘤;然而,组织病理学显示其为伴有大量淋巴管的淋巴管脂肪瘤样平滑肌瘤。据我们所知 在医学文献中这是首例此类病例描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13d/12237200/c39f241d7085/JMH-16-211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13d/12237200/fa00cc86ce93/JMH-16-211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13d/12237200/c39f241d7085/JMH-16-211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13d/12237200/fa00cc86ce93/JMH-16-211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f13d/12237200/c39f241d7085/JMH-16-211-g002.jpg

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本文引用的文献

1
Involvement of lymphatics in lymphangioleiomyomatosis.淋巴管平滑肌瘤病中淋巴管的累及情况。
Lymphat Res Biol. 2009 Dec;7(4):221-8. doi: 10.1089/lrb.2009.0017.
2
Sonographic evaluation of a uterine angiolipoleiomyoma.子宫血管平滑肌瘤的超声评估
J Clin Ultrasound. 2002 May;30(4):241-4. doi: 10.1002/jcu.10057.
3
Leiomyomas of the uterine cervix: a study of frequency.子宫颈平滑肌瘤:一项关于发病率的研究。
Int J Gynecol Pathol. 1998 Jul;17(3):231-4. doi: 10.1097/00004347-199807000-00006.
4
Lipoleiomyomatous tumors of the uterus: a heterogeneous group? Histopathological study of five cases.子宫脂肪平滑肌瘤:一组异质性肿瘤?5例组织病理学研究
Pathol Int. 1996 Jul;46(7):498-502. doi: 10.1111/j.1440-1827.1996.tb03644.x.
5
Lipomatous neometaplasia of the uterus. Report of 11 cases with discussion of histogenesis and pathogenesis.
Int J Gynecol Pathol. 1989;8(4):357-63. doi: 10.1097/00004347-198912000-00007.