Anum Qaira, Yossy Vesri, Fonna Nellia
Andalas University, Medical Faculty, Department of Dermatovenereology/ Dr. M. Djamil Hospital, Perintis Kemerdekaan, Padang, West Sumatera 25171, Indonesia.
Iran J Med Sci. 2025 Jun 1;50(6):423-428. doi: 10.30476/ijms.2025.102235.3695. eCollection 2025 Jun.
Anogenital warts, caused by human papillomavirus (HPV) infection, are characterized by papular lesions in the anogenital region. Acetowhite examination and dermoscopy are non-invasive methods that might aid in confirming the clinical diagnosis. This study aimed to evaluate the diagnostic accuracy of acetowhite examination and dermoscopy compared to histopathological findings in anogenital warts. This cross-sectional study included patients diagnosed with anogenital warts at Dr. M. Djamil Padang Hospital (Padang, Indonesia) from January 2023 to December 2023. Using the purposive sampling method, 62 lesions from 54 patients (28 men and 26 women) aged 16-59 years were analyzed. Each lesion underwent acetowhite examination, dermoscopy, and histopathological examination. Descriptive analyses were performed on subject characteristics and dermoscopic features, while sensitivity and specificity were calculated using a 2×2 table. The majority of lesions were found in the perianal area in men (44%) and the vulva in women (39%). The acetowhite examination demonstrated a sensitivity of 91% but lacked specificity and negative predictive value (NPV), indicating limitations in identifying negative results. In contrast, dermoscopy exhibited 100% sensitivity and specificity. The findings indicated that both acetowhite examination and dermoscopy were effective diagnostic tools for anogenital warts, with dermoscopy providing exceptional accuracy. These non-invasive methods could potentially reduce the need for more invasive histopathological procedures. Dermoscopy, in particular, serves as a sensitive and specific adjunct tool, offering reliable diagnostic capabilities that can enhance clinical practice.
尖锐湿疣由人乳头瘤病毒（HPV）感染引起，其特征为肛门生殖器区域出现丘疹性病变。醋酸白试验和皮肤镜检查是有助于确诊临床诊断的非侵入性方法。本研究旨在评估醋酸白试验和皮肤镜检查相对于尖锐湿疣组织病理学结果的诊断准确性。这项横断面研究纳入了2023年1月至2023年12月在印度尼西亚巴东M. 贾米尔博士医院（巴东）被诊断为尖锐湿疣的患者。采用目的抽样法，分析了54例年龄在16 - 59岁（28名男性和26名女性）患者的62处病变。对每处病变进行了醋酸白试验、皮肤镜检查和组织病理学检查。对受试者特征和皮肤镜特征进行了描述性分析，同时使用2×2列联表计算敏感性和特异性。大多数病变在男性的肛周区域（44%）和女性的外阴（39%）被发现。醋酸白试验的敏感性为91%，但缺乏特异性和阴性预测值（NPV），表明在识别阴性结果方面存在局限性。相比之下，皮肤镜检查的敏感性和特异性均为100%。研究结果表明，醋酸白试验和皮肤镜检查都是诊断尖锐湿疣的有效工具，皮肤镜检查具有极高的准确性。这些非侵入性方法可能会减少对更具侵入性的组织病理学检查的需求。特别是皮肤镜检查，作为一种敏感且特异的辅助工具，具有可靠的诊断能力，可提升临床实践水平。
