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肝移植量与心肺移植项目存在情况的关联:对器官获取与移植网络(SRTR)指标的分析

Liver transplant volume association with presence of heart and lung transplant programs: analysis of SRTR metrics.

作者信息

Patil Sanath, Siddique Faizaan, Rahimov Daler, Rajagopal Keshava, Entwistle John W, Bodzin Adam, Tchantchaleishvili Vakhtang

机构信息

Department of Cardiac Surgery, Thomas Jefferson University, 1025 Walnut St, Suite 607, Philadelphia, PA, 19107, USA.

Division of Transplant Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

Gen Thorac Cardiovasc Surg. 2025 Jul 10. doi: 10.1007/s11748-025-02178-3.

DOI:10.1007/s11748-025-02178-3
PMID:40637786
Abstract

PURPOSE

We sought to understand how centers transplanting liver only (L0), centers transplanting heart and liver (LH), and centers transplanting liver, heart, and lung (LHL) differ regarding volume, waitlist and post-transplant outcomes.

METHODS

Data were collected from the Scientific Registry of Transplant Recipients (SRTR) in July 2023. SRTR star ratings were categorized into five tiers, with one being the lowest tier and five the highest tier.

RESULTS

Median liver transplant volumes were 35 [IQR: 14-51] for L0 centers, 45 [10-75] for LH centers, and 101 [69-131] for LHL centers (p < 0.001). Liver waitlist survival (p = 0.13), waitlist duration (p = 0.31) and 1-year survival ratings (p = 0.32) were comparable across all 3 categories. Annual transplant volume was associated with a higher SRTR waitlist duration rating (p < 0.001) but not with 1-year post-transplant survival (p = 0.51).

CONCLUSION

The presence of a heart transplant and lung transplant programs in liver transplant centers is associated with higher liver transplant volumes, translating to higher waitlist duration tier ratings for liver recipients, but not to improved 1-year post-transplant survival.

摘要

目的

我们试图了解仅进行肝脏移植的中心(L0)、进行心脏和肝脏移植的中心(LH)以及进行肝脏、心脏和肺移植的中心(LHL)在移植量、等待名单和移植后结果方面有何不同。

方法

2023年7月从移植受者科学注册系统(SRTR)收集数据。SRTR星级分为五个等级,一级为最低等级,五级为最高等级。

结果

L0中心肝脏移植量中位数为35[四分位间距:14 - 51],LH中心为45[10 - 75],LHL中心为101[69 - 131](p < 0.001)。所有三个类别在肝脏等待名单生存率(p = 0.13)、等待名单持续时间(p = 0.31)和1年生存率评级(p = 0.32)方面具有可比性。年度移植量与SRTR等待名单持续时间评级较高相关(p < 0.001),但与移植后1年生存率无关(p = 0.51)。

结论

肝脏移植中心存在心脏移植和肺移植项目与更高的肝脏移植量相关,这意味着肝脏受者的等待名单持续时间评级更高,但移植后1年生存率并未提高。

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本文引用的文献

1
Patient Selection in Low-Volume Heart Transplant Centers: Challenges and Ethical Implications.低容量心脏移植中心的患者选择:挑战与伦理意义
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The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis.供体风险指数、受者及手术特征对肝移植术后一年移植物失败的影响:一项队列分析。
GE Port J Gastroenterol. 2022 Apr 28;30(4):275-282. doi: 10.1159/000524421. eCollection 2023 Aug.
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Association of Heart Transplant Volume with Presence of Lung Transplant Programs and Heart Transplant's SRTR One-year Survival Rating.
心脏移植量与肺移植项目的存在以及心脏移植 SRTR 一年生存率的关系。
Thorac Cardiovasc Surg. 2024 Jun;72(4):261-265. doi: 10.1055/a-2095-6636. Epub 2023 May 17.
4
Regional transplant rates depend more on physician-dependent variables than on proximity to transplant center.区域移植率更多地取决于依赖医生的变量,而不是与移植中心的距离。
Langenbecks Arch Surg. 2023 May 12;408(1):191. doi: 10.1007/s00423-023-02874-9.
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Impact of institutional case volume of solid organ transplantation on patient outcomes and implications for healthcare policy in Korea.韩国实体器官移植机构病例数量对患者预后的影响及对医疗政策的启示
Korean J Transplant. 2023 Mar 31;37(1):1-10. doi: 10.4285/kjt.23.0010.
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Nat Rev Gastroenterol Hepatol. 2023 Jun;20(6):388-398. doi: 10.1038/s41575-023-00759-2. Epub 2023 Mar 28.
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Clin Mol Hepatol. 2023 Feb;29(Suppl):S32-S42. doi: 10.3350/cmh.2022.0365. Epub 2022 Dec 14.
8
The volume-outcomes relationship in donation after circulatory death liver transplantation.在循环死亡供肝肝移植中,体积与结果的关系。
Clin Transplant. 2022 Jun;36(6):e14658. doi: 10.1111/ctr.14658. Epub 2022 Apr 25.
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From Child-Pugh to MELD score and beyond: Taking a walk down memory lane.从Child-Pugh评分到终末期肝病模型(MELD)评分及其他:回顾往昔。
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Liver Transplant Center Size and the Impact on Clinical Outcomes and Resource Utilization.肝移植中心规模及其对临床结局和资源利用的影响。
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