PURPOSE: To develop a holographic skull model of a deformity resulting from craniosynostosis for the HoloLens. METHODS: The methodology for product creation and prototyping was the design thinking structured with the double diamond. A desk survey was conducted with a literature review and an anteriority search. Based on the desk survey results, brainstorming was performed to develop solutions to improve the surgeon's performance in craniosynostosis using mixed reality. RESULTS: Reports or scientific articles relating mixed reality use to craniosynostosis were not found in search engines or bibliography databases. A surgeon's performance potential improvement was observed using mixed reality as an auxiliary tool in craniosynostosis surgery. A craniosynostosis skull hologram was developed in mixed reality, with interactivity commands controlled by gestures, facilitating a three-dimensional spatial understanding of cranial anatomy. CONCLUSION: A holographic skull model with a deformity resulting from craniosynostosis was developed for the HoloLens.