Barbier Michaela Carla, Galactionova Katya, Lambiris Mark, Oliveira Leonel, Rüter Florian, Glinz Dominik, Thürmer Jessica, Pletscher Flurina, Kasenda Benjamin, Finazzi Tobias, König David, Lardinois Didier, Conrad Larissa, Mutz Leonie, Schwenkglenks Matthias
Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland.
Health Economics Facility, Department of Public Health, University of Basel, Basel, Switzerland.
PLoS One. 2025 Jul 10;20(7):e0327814. doi: 10.1371/journal.pone.0327814. eCollection 2025.
The concept of Value-Based Health Care (VBHC) seeks to maximise patient value by optimising health outcomes considering costs. However, necessary data are not readily available. In Switzerland, hospital accounting is disconnected from patient outcomes and treatment data. We demonstrate the feasibility of merging routine hospital data, including patient-reported outcome measures (PROMs), to implement core elements of VBHC in a real-world lung cancer centre.
We developed a merging approach using records from 208 newly diagnosed lung cancer patients treated at University Hospital Basel between June 2020 and November 2023. Maximum patient follow-up was 12-months. Clinician-reported outcome measure (CROM) and PROM data collection followed the International Consortium for Health Outcomes Measurement (Lung Cancer Set) standard. Cost data were extracted from Switzerland's standard hospital accounting system (REKOLE®). To illustrate analytical options offered by the merged data, we analysed partial correlations between costs and utility changes from baseline.
The merging approach successfully allocated costs to specific lung cancer treatments and separated costs for comorbidity care, enabling an initial presentation of cost distributions for different elements of care. Median total first-year hospital costs per lung cancer patient were CHF 77,834 (mean CHF 93,621). Immunotherapy incurred the highest median costs of CHF 45,394 (mean CHF 49,518), followed by surgery of CHF 41,665 (mean CHF 48,940). First-year costs for patients diagnosed with stage I tended to be lower than for later stages. A standard graphical tool was developed to track individual patient treatment, outcome, and cost over time.
This proof-of-concept analysis demonstrates the feasibility of a novel data merging approach as a foundation for VBHC implementation. While limited by sample size and follow-up duration, our method supports future treatment-cost-benefit models. It is reproducible and scalable across other conditions and hospitals, enabling the development of lung cancer treatments towards greater value and efficiency.
基于价值的医疗保健(VBHC)概念旨在通过在考虑成本的情况下优化健康结果,使患者价值最大化。然而,所需数据并非随时可得。在瑞士,医院会计与患者结果及治疗数据脱节。我们展示了合并常规医院数据(包括患者报告的结局指标(PROMs))以在一家现实世界中的肺癌中心实施VBHC核心要素的可行性。
我们开发了一种合并方法,使用2020年6月至2023年11月期间在巴塞尔大学医院接受治疗的208例新诊断肺癌患者的记录。患者的最长随访时间为12个月。临床医生报告的结局指标(CROM)和PROM数据收集遵循国际健康结局测量联盟(肺癌数据集)标准。成本数据从瑞士的标准医院会计系统(REKOLE®)中提取。为了说明合并后的数据所提供的分析选项,我们分析了成本与基线效用变化之间的偏相关性。
该合并方法成功地将成本分配到特定的肺癌治疗中,并分离了合并症护理的成本,从而能够初步呈现不同护理要素的成本分布情况。每位肺癌患者第一年的医院总费用中位数为77,834瑞士法郎(平均93,621瑞士法郎)。免疫疗法的费用中位数最高,为45,394瑞士法郎(平均49,518瑞士法郎),其次是手术,费用为41,665瑞士法郎(平均48,940瑞士法郎)。诊断为I期的患者第一年的费用往往低于后期阶段的患者。开发了一种标准图形工具来跟踪个体患者的治疗、结局和成本随时间的变化。
这一概念验证分析证明了一种新颖的数据合并方法作为实施VBHC基础的可行性。虽然受到样本量和随访时间的限制,但我们的方法支持未来的治疗成本效益模型。它在其他疾病和医院中具有可重复性和可扩展性,有助于推动肺癌治疗朝着更高的价值和效率发展。