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CAR T cell therapy-related lumbosacral polyradiculopathy with myelitis and stiff person syndrome with response to intravenous immunoglobulin and corticosteroids in a patient with acute lymphoblastic leukemia.

作者信息

Goulart Hannah, Elmore Kevin, Scelsa Stephen, Park Daniel, Keyzner Alla, Ibrahim Uroosa

机构信息

Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, USA.

Department of Neuro-oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

出版信息

Hematol Transfus Cell Ther. 2025 Jul 9;47(3):103932. doi: 10.1016/j.htct.2025.103932.

DOI:10.1016/j.htct.2025.103932
PMID:40639061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12274311/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1be/12274311/340cc141e4e9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1be/12274311/340cc141e4e9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1be/12274311/340cc141e4e9/gr1.jpg

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本文引用的文献

1
Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases.甘氨酸受体抗体综合征的新临床特征：17 例系列病例。
Neurol Neuroimmunol Neuroinflamm. 2019 Jul 1;6(5):e592. doi: 10.1212/NXI.0000000000000592. eCollection 2019 Sep.
2
Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells.嵌合抗原受体 T 细胞过继免疫治疗后的神经毒性的临床表现、治疗和生物标志物。
Blood. 2019 May 16;133(20):2212-2221. doi: 10.1182/blood-2018-12-893396. Epub 2019 Feb 26.
3
ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells.
ASTCT 细胞因子释放综合征和免疫效应细胞相关神经系统毒性的共识分级标准。
Biol Blood Marrow Transplant. 2019 Apr;25(4):625-638. doi: 10.1016/j.bbmt.2018.12.758. Epub 2018 Dec 25.
4
Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management.嵌合抗原受体 T 细胞毒性的最新进展：机制、表现和管理。
Blood Rev. 2019 Mar;34:45-55. doi: 10.1016/j.blre.2018.11.002. Epub 2018 Nov 14.
5
Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.与 B 细胞急性淋巴细胞白血病患者的 CAR T 细胞治疗相关的神经毒性的临床和生物学相关性。
Cancer Discov. 2018 Aug;8(8):958-971. doi: 10.1158/2159-8290.CD-17-1319. Epub 2018 Jun 7.
6
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.单核细胞衍生的白细胞介素-1 和白细胞介素-6 对于 CAR T 细胞引起的细胞因子释放综合征和神经毒性是有差异需求的。
Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28.
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Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.嵌合抗原受体 T 细胞介导的非人灵长类动物神经毒性。
Cancer Discov. 2018 Jun;8(6):750-763. doi: 10.1158/2159-8290.CD-17-1368. Epub 2018 Mar 21.
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Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.急性淋巴细胞白血病中CD19嵌合抗原受体疗法的长期随访
N Engl J Med. 2018 Feb 1;378(5):449-459. doi: 10.1056/NEJMoa1709919.
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N Engl J Med. 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866.
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Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.嵌合抗原受体 T 细胞过继免疫治疗后神经毒性中的血管内皮细胞激活和血脑屏障破坏。
Cancer Discov. 2017 Dec;7(12):1404-1419. doi: 10.1158/2159-8290.CD-17-0698. Epub 2017 Oct 12.