Dillard Joseph P
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.
Cell Host Microbe. 2025 Jul 9;33(7):1048-1049. doi: 10.1016/j.chom.2025.05.019.
In this issue, Kurt-Jones et al. demonstrate a surprising role for the type I interferon, IFN-ε, in Neisseria gonorrhoeae infections of the female reproductive tract. Rather than protecting the host, IFN-ε increases CMP-sialic acid production in epithelial cells, potentiating sialic acid modification of bacterial lipooligosaccharide, enabling innate immune evasion.
在本期杂志中，库尔特 - 琼斯等人证明了I型干扰素IFN-ε在女性生殖道淋病奈瑟菌感染中发挥了惊人作用。IFN-ε非但没有保护宿主，反而增加了上皮细胞中CMP-唾液酸的产生，增强了细菌脂寡糖的唾液酸修饰，从而实现先天免疫逃逸。
