下丘脑催乳素信号传导可预防孕期体温过高。
Hypothalamic prolactin signaling protects against overheating in pregnancy.
作者信息
Cortes Laura R, Correa Stephanie M
机构信息
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90077, USA.
出版信息
Trends Neurosci. 2025 Aug;48(8):555-556. doi: 10.1016/j.tins.2025.07.001. Epub 2025 Jul 9.
Abstract
Pregnancy involves physiological adaptations that optimize fetal development. Reduced maternal core temperature may protect offspring from the teratogenic effects of excess heat, but the mechanisms regulating body temperature during pregnancy remained largely unclear. In a recent study in mice, Ladyman and colleagues identified the prolactin receptor (Prlr) as a thermal switch lowering maternal core temperature and promoting offspring survival in warm environments.
摘要
怀孕涉及生理适应性变化，这些变化能优化胎儿发育。母体核心体温降低可能会保护后代免受过热的致畸影响，但孕期调节体温的机制在很大程度上仍不清楚。在最近一项对小鼠的研究中，Ladyman及其同事确定催乳素受体（Prlr）是一种热开关，可降低母体核心体温并促进后代在温暖环境中的存活。
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