Shu Lin, Wang Huan, Jian Ziqing, Zhou Zhike, Xu Yanli, Zhang Ye, Chen Yanyan
Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guilin Medical University, Guilin 541199, China.
J Org Chem. 2025 Jul 25;90(29):10352-10368. doi: 10.1021/acs.joc.5c01026. Epub 2025 Jul 10.
A transition metal-free photocatalytic addition/cyclization of 2-allylaminobenzonitriles with -difluoromethyl radicals has been developed, constructing phenanthridine derivatives in moderate to good yields. The strongly reducing arylamine was employed as a photocatalyst in the reaction, which tolerated tertiary amines and efficiently enabled the conversion of -difluoromethyl radical precursors into radical species. The obtained novel phenanthridine derivatives exhibited blue to green emissions at the range of 390-540 nm, showing potential application in fluorescent dye.
已开发出一种无过渡金属的光催化反应，即2-烯丙基氨基苯甲腈与二氟甲基自由基进行加成/环化反应，以中等至良好的产率构建菲啶衍生物。反应中使用强还原性芳胺作为光催化剂，该催化剂能耐受叔胺，并有效地将二氟甲基自由基前体转化为自由基物种。所得到的新型菲啶衍生物在390-540nm范围内呈现蓝色至绿色发射，在荧光染料方面显示出潜在应用。
