Wang Dong, Ji Lei, Li You, Xu Meng, Wang Hao, Brovelli Sergio, Qiao Zeng-Ying, Zhang Jiatao, Li Yadong
Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Institute of Medical-Industrial Integration, Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.
CAS Center for Excellence in Nanoscience, Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China.
Nat Nanotechnol. 2025 Aug;20(8):1098-1107. doi: 10.1038/s41565-025-01943-y. Epub 2025 Jul 10.
Chemodynamic therapy and sonodynamic therapy are two promising tumour therapeutic strategies. However, lack of highly effective sonosensitizers and control over chemodynamic therapy limit their application. Here we synthesize silver-doped zinc selenide quantum dots with atomically dispersed superficial Fe and show that they act as efficient sonosensitizers, catalysers and immunoreagents. Surface modification with an in situ self-assembly peptide drives accumulation in tumours. Superficial Fe remains stable and converts to Fe only under ultrasonic processing, reverting to Fe upon ultrasound cessation. Under ultrasound stimulation, superficial Fe undergoes valence change with concomitant amelioration of the hypoxic tumour microenvironment and production of sonodynamic therapy-beneficial hydroxyl radicals. Furthermore, silver doping suppressed nonradiative recombination of excitons, leading to improved production of singlet oxygen. Meanwhile, selenium promotes robust systemic immune responses for the inhibition of tumour metastases. This nano-platform allows control of valence switching of atomically dispersed catalysts, representing an effective tool for chemodynamic/sonodynamic/immunotherapy.
化学动力疗法和超声动力疗法是两种很有前景的肿瘤治疗策略。然而，缺乏高效的超声敏化剂以及对化学动力疗法的控制限制了它们的应用。在此，我们合成了具有原子分散表面铁的银掺杂硒化锌量子点，并表明它们可作为高效的超声敏化剂、催化剂和免疫试剂。用原位自组装肽进行表面修饰可促使其在肿瘤中积累。表面铁保持稳定，仅在超声处理下转化为亚铁，超声停止后又恢复为铁。在超声刺激下，表面铁发生价态变化，同时改善缺氧肿瘤微环境并产生有利于超声动力疗法的羟基自由基。此外，银掺杂抑制了激子的非辐射复合，从而提高了单线态氧的产生。同时，硒促进强大的全身免疫反应以抑制肿瘤转移。这种纳米平台可控制原子分散催化剂的价态转换，是化学动力/超声动力/免疫疗法的有效工具。
