Tian Chongmei, Fang Yuejuan, You Zhixin, Li Huijiao, Zhao Yaping, Chen Jingbai, Dong Su, Jiang Lihua
Department of Pharmacy, Shaoxing Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Shaoxing, Zhejiang, 312000, China.
Department of Pharmacy, Quzhou Maternal and Child Health Care Hospital, Quzhou, 324000, China.
BMC Geriatr. 2025 Jul 10;25(1):514. doi: 10.1186/s12877-025-06124-z.
Systemic lupus erythematosus (SLE) is a common autoimmune disease affecting various organs. Cryptococcus neoformans, an environmental yeast that is heavily dependent on the complement cascade for natural host defense, is produced via inhalation in immunocompromised patients. The fungal pathogen, C. neoformans, can cause life-threatening infections in patients with SLE. Acinetobacter baumannii is a nosocomial pathogen that causes healthcare-associated infections, particularly in immunocompromised and critically ill patients. However, reports of co-infection with C. neoformans and A. baumannii in patients with SLE are scarce. We report an interesting case of co-infection with C. neoformans and A. baumannii in an 85-year-old man presented with cough, expectoration, chest tightness, and shortness of breath five months after diagnosis of SLE. The patient recovered gradually after 18 days of antimicrobial therapy. Coinfection with C. neoformans and A. baumannii in patients with SLE is rare, difficult to diagnose early, and has a high mortality rate. Accurate diagnosis and timely treatment are lifesaving.
系统性红斑狼疮（SLE）是一种影响多个器官的常见自身免疫性疾病。新型隐球菌是一种环境酵母菌，严重依赖补体级联反应进行天然宿主防御，在免疫功能低下的患者中通过吸入产生。真菌病原体新型隐球菌可在SLE患者中引起危及生命的感染。鲍曼不动杆菌是一种医院病原体，可引起医疗保健相关感染，尤其是在免疫功能低下和重症患者中。然而，SLE患者合并新型隐球菌和鲍曼不动杆菌感染的报道很少。我们报告了一例有趣的病例，一名85岁男性在诊断为SLE五个月后出现咳嗽、咳痰、胸闷和气短，合并新型隐球菌和鲍曼不动杆菌感染。患者在接受18天抗菌治疗后逐渐康复。SLE患者合并新型隐球菌和鲍曼不动杆菌感染很少见，早期难以诊断，死亡率高。准确诊断和及时治疗可挽救生命。
