Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nat Immunol. 2024 Aug;25(8):1332-1343. doi: 10.1038/s41590-024-01898-7. Epub 2024 Jul 15.
Understanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches to understand the nature of the disease have identified many pathogenetic contributors that parallel clinical heterogeneity. This Review outlines the immunological control of SLE and looks to experimental tools and approaches that are improving our understanding of the complex contribution of interacting genetics, environment, sex and immunoregulatory factors and their interface with processes inherent to tissue parenchymal cells. Efforts to advance precision medicine in the care of patients with SLE along with treatment strategies to correct the immune system hold hope and are also examined.
了解系统性红斑狼疮（SLE）的发病机制和临床表现一直是一个巨大的挑战。还原论方法来了解疾病的本质已经确定了许多与临床异质性平行的发病因素。这篇综述概述了 SLE 的免疫控制，并着眼于实验工具和方法，这些方法正在提高我们对相互作用的遗传、环境、性别和免疫调节因素及其与组织实质细胞固有过程的界面的复杂贡献的理解。沿着治疗 SLE 患者免疫系统的策略，为推进 SLE 患者的精准医疗所做的努力也进行了探讨。
