肝素与乙酰胆碱酯酶多分子聚集体的相互作用。
Interaction of heparin with multimolecular aggregates of acetylcholinesterase.
作者信息
Torres J C, Inestrosa N C
出版信息
Cell Mol Neurobiol. 1985 Sep;5(3):303-9. doi: 10.1007/BF00711015.
Abstract
It has been reported previously that heparin, a sulfated glycosaminoglycan, releases the asymmetric 16 S form of acetylcholinesterase (AChE) from cholinergic synapses. Here it is shown that heparin releases the synaptic AChE not as individual 16 S species but as multimolecular aggregates (30 S) of such molecules. Heparin is able to convert low-ionic strength AChE aggregates into a heparin type of AChE aggregates. Our results suggest that the AChE aggregates detached by heparin are likely to be the physiologically important state of aggregation of the 16 S AChE form in the synaptic basal lamina.
摘要
先前已有报道称，硫酸化糖胺聚糖肝素可从胆碱能突触释放不对称的16S形式的乙酰胆碱酯酶（AChE）。本文表明，肝素释放的突触AChE并非单个16S分子，而是此类分子的多分子聚集体（30S）。肝素能够将低离子强度的AChE聚集体转化为肝素型AChE聚集体。我们的结果表明，肝素分离出的AChE聚集体可能是突触基底层中16S AChE形式在生理上重要的聚集状态。
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