The role of the inter-heavy chain disulfide bond in modulating the flexibility of immunoglobulin G antibody.

Suppr

超能文献

作者信息

Chan L M, Cathou R E

出版信息

J Mol Biol. 1977 Jun 5;112(4):653-6. doi: 10.1016/s0022-2836(77)80170-8.

DOI:10.1016/s0022-2836(77)80170-8

PMID:406410

Abstract

摘要

相似文献

The role of the inter-heavy chain disulfide bond in modulating the flexibility of immunoglobulin G antibody.

J Mol Biol. 1977 Jun 5;112(4):653-6. doi: 10.1016/s0022-2836(77)80170-8.

Role of inter-heavy and light chain disulfide bonds in the effector functions of human immunoglobulin IgG1.重链与轻链间二硫键在人免疫球蛋白IgG1效应功能中的作用

Mol Immunol. 1992 Dec;29(12):1487-91. doi: 10.1016/0161-5890(92)90222-j.

Sequence analysis of human J chain. Amino terminal location of a disulfide bond linking the immunoglobulin heavy chain.

Biochem Biophys Res Commun. 1976 Nov 8;73(1):92-7. doi: 10.1016/0006-291x(76)90501-5.

Covalent immunoglobulin assembly in vitro: reactivity of light chain covalent dimers (L2) and blocked light chain monomers.

Science. 1978 Feb 10;199(4329):688-90. doi: 10.1126/science.415360.

A molecular-mechanics study of the conformation of the interchain disulfide of human immunoglobulin G4 (IgG4).

Mol Immunol. 1988 Oct;25(10):1019-24. doi: 10.1016/0161-5890(88)90009-0.

The inter-chain disulfide bonds of a mu-chain disease protein.一种μ链病蛋白的链间二硫键。

FEBS Lett. 1974 Oct 15;47(2):264-7. doi: 10.1016/0014-5793(74)81026-4.

Intrachain disulfide bond in the core hinge region of human IgG4.人IgG4核心铰链区的链内二硫键

Protein Sci. 1997 Feb;6(2):407-15. doi: 10.1002/pro.5560060217.

The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.免疫球蛋白结构域的结构与功能。II. 链间二硫键的重要性以及分子柔性在免疫球蛋白G与补体相互作用中的可能作用。

J Immunol. 1975 Jun;114(6):1726-9.

Structural characterization of immunoglobulin G using time-dependent disulfide bond reduction.利用时间依赖性二硫键还原对免疫球蛋白G进行结构表征。

Anal Biochem. 2009 Jan 15;384(2):368-70. doi: 10.1016/j.ab.2008.10.012. Epub 2008 Oct 17.

Molecular structural studies of effector functions of a mouse immunoglobulin G that lacks the entire CH1 domain: small-angle X-ray scattering, nanosecond fluorescence depolarization and stable isotope-aided NMR analyses.缺乏整个CH1结构域的小鼠免疫球蛋白G效应功能的分子结构研究：小角X射线散射、纳秒荧光去极化和稳定同位素辅助核磁共振分析

Mol Immunol. 1993 Dec;30(18):1665-9. doi: 10.1016/0161-5890(93)90440-m.

引用本文的文献

Continuous Fluorescence Depletion Anisotropy Measurement of Protein Rotation.蛋白质旋转的连续荧光耗尽各向异性测量

J Fluoresc. 2018 Mar;28(2):533-542. doi: 10.1007/s10895-018-2214-7. Epub 2018 Feb 3.

Fast antibody fragment motion: flexible linkers act as entropic spring.快速抗体片段运动：柔性接头充当熵弹簧。

Sci Rep. 2016 Mar 29;6:22148. doi: 10.1038/srep22148.

Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function.IgG 分子的二硫键结构：结构变异、化学修饰以及对稳定性和生物学功能的可能影响。

MAbs. 2012 Jan-Feb;4(1):17-23. doi: 10.4161/mabs.4.1.18347.

Effect of cleaving interchain disulfide bridges on the radius of gyration and maximum length of anti-poly(D-alanyl) antibodies before and after reaction with tetraalanine hapten.切割链间二硫键对与四丙氨酸半抗原反应前后抗聚（D-丙氨酰）抗体的回转半径和最大长度的影响。

Proc Natl Acad Sci U S A. 1980 Jan;77(1):117-21. doi: 10.1073/pnas.77.1.117.

A monoclonal antibody to human brain-type creatine kinase. Increased avidity with mercaptans.一种针对人脑型肌酸激酶的单克隆抗体。与硫醇的亲和力增加。

Biochem J. 1983 Dec 1;215(3):505-12. doi: 10.1042/bj2150505.

Antibody organization on lipid films. Influence of pH and interchain disulphide reduction.脂质膜上的抗体组装。pH值和链间二硫键还原的影响。

Biochem J. 1990 Nov 15;272(1):45-9. doi: 10.1042/bj2720045.

Large-scale rotational motions of proteins detected by electron paramagnetic resonance and fluorescence.通过电子顺磁共振和荧光检测到的蛋白质大规模旋转运动。

Biophys J. 1978 Nov;24(2):439-62. doi: 10.1016/S0006-3495(78)85394-6.

Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond.重链间二硫键还原后IgG四级结构的变化。

Proc Natl Acad Sci U S A. 1979 Feb;76(2):907-11. doi: 10.1073/pnas.76.2.907.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验