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血清NADPH氧化酶2水平在预测重度创伤性脑损伤后180天临床结局中的应用：一项前瞻性队列分析

Application of Serum NADPH Oxidase 2 Levels for Predicting 180-Day Clinical Outcomes Following Severe Traumatic Brain Injury: A Prospective Cohort Analysis.

作者信息

Su Chang, Shen Dapu, Xu Junlong, Chen Miaomiao, He Heng, Ye Jianping

机构信息

Department of Neurosurgery, Lishui Hospital of Wenzhou Medical University, Lishui City People's Hospital, Lishui, Zhejiang Province, China.

Department of Intensive Care Unit, Lishui Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui, Zhejiang Province, China.

出版信息

Brain Behav. 2025 Jul;15(7):e70692. doi: 10.1002/brb3.70692.

DOI:10.1002/brb3.70692
PMID:40641341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12246553/
Abstract

OBJECTIVES

Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) affects oxidative response to acute brain injury. We set out to determine if there are connections between serum NOX2 levels, severity, and subsequent clinical outcomes of severe traumatic brain injury (sTBI).

METHODS

In this prospective cohort study, serum NOX2 levels were measured in 123 patients and 123 controls. The Glasgow Coma Scale (GCS) scores and Rotterdam computed tomography (CT) classifications were applied for assessing injury severity. A poor prognosis was considered if the Glasgow Outcome Scale Extended (GOSE) score was 4 or below at 180 days post-injury.

RESULTS

STBI patients exhibited markedly enhanced serum NOX2 levels relative to healthy controls, and serum NOX2 levels were independently linked to Rotterdam CT classifications and GCS scores. Serum NOX2 levels effectively identified individuals at risk of death or poor prognosis at 180-day after sTBI. When compared to GCS scores and Rotterdam CT classifications, its predictive power was comparable. When the three variables were utilized together, the model's predictive ability was significantly higher than when they were independently used.

CONCLUSIONS

NOX2 might be used as a potential biomarker to assess the severity of sTBI and foretell its outcome, since elevated serum NOX2 levels are significantly linked to increasing severity, 180-day mortality, and poor prognosis after sTBI.

摘要

目的

烟酰胺腺嘌呤二核苷酸磷酸氧化酶2（NOX2）影响急性脑损伤的氧化反应。我们旨在确定血清NOX2水平、严重程度以及重度创伤性脑损伤（sTBI）后续临床结局之间是否存在关联。

方法

在这项前瞻性队列研究中，对123例患者和123名对照者测量血清NOX2水平。应用格拉斯哥昏迷量表（GCS）评分和鹿特丹计算机断层扫描（CT）分类来评估损伤严重程度。如果伤后180天时格拉斯哥预后量表扩展版（GOSE）评分为4分或更低，则认为预后不良。

结果

与健康对照者相比，sTBI患者血清NOX2水平显著升高，且血清NOX2水平与鹿特丹CT分类和GCS评分独立相关。血清NOX2水平能有效识别sTBI后180天时死亡或预后不良风险的个体。与GCS评分和鹿特丹CT分类相比，其预测能力相当。当将这三个变量一起使用时，模型的预测能力显著高于单独使用时。

结论

NOX2可能用作评估sTBI严重程度和预测其结局的潜在生物标志物，因为血清NOX2水平升高与sTBI严重程度增加、180天死亡率和预后不良显著相关。

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Traumatic Brain Injury: A Comprehensive Review of Biomechanics and Molecular Pathophysiology.颅脑创伤：生物力学和分子病理生理学的综合评述。
World Neurosurg. 2024 May;185:74-88. doi: 10.1016/j.wneu.2024.01.084. Epub 2024 Jan 23.
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Performance of plasma von Willebrand factor in acute traumatic brain injury: relations to severity, CT findings, and outcomes.急性创伤性脑损伤中血浆血管性血友病因子的表现：与严重程度、CT表现及预后的关系
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Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months.
运用代谢组学预测严重创伤性脑损伤患者在 3 个月和 12 个月时的格拉斯哥预后评分（GOSE）。
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Elevated Serum NOX2 Levels Contribute to Delayed Cerebral Ischemia and a Poor Prognosis After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.血清NOX2水平升高导致动脉瘤性蛛网膜下腔出血后迟发性脑缺血和预后不良：一项前瞻性队列研究
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