Hu Zhiwei, Yin Yongchao, Yang Xiaoli, Zhang Hanyang, Xing Ling, Zhang Shiwu, Gong Xinglong, Wu Ming, Yun Guolin, Sun Shuaishuai
The First Affiliated Hospital of USTC, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Institute of Humanoid Robots, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, 230026, China.
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Adv Sci (Weinh). 2025 Sep;12(34):e05259. doi: 10.1002/advs.202505259. Epub 2025 Jul 11.
Functional electrical stimulation (FES) enhances daily living and rehabilitation outcomes for stroke patients but faces challenges in intention recognition, individual adaptability, and closed-loop control. To address these, a reconstruction system is presented for upper limb motor function, employing highly pressure-sensitive liquid metal magnetorheological elastomers (LMMRE) to detect muscle surface pressure. It can dynamically modulate functional electrical stimulation based on muscle force signals, enabling continuous execution of wrist movements for stroke patients. The system markedly improves patient mobility, with wrist lifting angles increased from 14° to 47°, and lifting speed nearly doubled. Clinical trials confirm the system's superior efficacy in promoting motor recovery and reducing muscle spasms. Moreover, functional near-infrared spectroscopy highlights enhanced brain activity and promotes reconstruction of damaged neural pathways during LMMRE-FES therapy compared with the conventional electrical stimulation. This system holds immense potential for advancing stroke rehabilitation, paving the way for portable, wearable devices optimized for home-based care.
功能性电刺激(FES)可改善中风患者的日常生活和康复效果,但在意图识别、个体适应性和闭环控制方面面临挑战。为解决这些问题,提出了一种用于上肢运动功能的重建系统,该系统采用高压力敏感液态金属磁流变弹性体(LMMRE)来检测肌肉表面压力。它可以根据肌肉力信号动态调节功能性电刺激,使中风患者能够连续执行腕部运动。该系统显著提高了患者的活动能力,腕部抬起角度从14°增加到47°,抬起速度几乎翻倍。临床试验证实了该系统在促进运动恢复和减少肌肉痉挛方面的卓越疗效。此外,功能近红外光谱显示,与传统电刺激相比,在LMMRE-FES治疗期间大脑活动增强,促进了受损神经通路的重建。该系统在推进中风康复方面具有巨大潜力,为优化家庭护理的便携式可穿戴设备铺平了道路。