Epidemiology, Risk Factors and Clinical Outcome of Candidaemia: .

OBJECTIVES

This study aimed to examine a decade-long epidemiology of candidaemia to explore the risk factors associated with it, and describe its clinical outcomes in hospitalised adult patients.

METHODS

This retrospective observational study was conducted at Sultan Qaboos University Hospital, Muscat, Oman. Adult patients with candidaemia hospitalised between January 2007 and December 2016 were included. The hospital infection control department surveillance registry on bloodstream infections (BSIs) was used to identify BSIs. Patients' electronic medical records were searched for demographic characteristics, clinical risk factors and outcomes.

RESULTS

was the most common species among 152 patients with candidaemia comprising 25.0% of all blood culture isolates. , and were the most frequently isolated non- species. Past antibiotics use, presence of central venous catheters, intensive care unit admission, diabetes mellitus, sickle cell disease and solid cancer were the most commonly identified underlying risk factors for candidaemia. A total of 30 days' all-cause mortality was 53.3% among all patients with candidaemia.

CONCLUSIONS

This study found an increasing trend of non- Diabetes was the most identified risk factor for candidaemia. A relatively low rate of initiation of empirical antifungal therapy in at-risk patients was found. Unacceptably high mortality rates and prolonged hospital stay of patients with candidaemia are a call for action.