Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, UAE; Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
Department of Clinical Science, College of Dentistry, Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE.
Int Dent J. 2023 Feb;73(1):42-47. doi: 10.1016/j.identj.2022.06.028. Epub 2022 Jul 28.
Odontogenic lesions evolve as a result of altered dental development. This study aimed to evaluate the prevalence and the coinfection of Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in radicular cysts, dentigerous cysts, odontogenic keratocysts, and ameloblastomas.
Polymerase chain reaction (PCR) was used to analyse 66 cases of odontogenic lesions for the presence of EBV-DNA and KSHV-DNA. These lesions were 15 radicular cysts, 16 dentigerous cysts, 18 odontogenic keratocysts, and 17 ameloblastomas.
EBV-DNA was detected in 24 (36.4%) of the studied samples as follows: 6 samples (40.0%) of radicular cysts, 4 (25.0%) of dentigerous cysts, 10 (55.6 %) of odontogenic keratocysts, and 4 (23.5%) of ameloblastomas (P = .168). KSHV-DNA was found in 16 (24.2%) of the studied samples as follows: 1 sample (6.7%) of radicular cysts, 6 (37.5%) of dentigerous cysts, 8 (44.4 %) of odontogenic keratocysts, and 1 (5.9%) of ameloblastomas (P = .001). Additionally, EBV and KSHV were positively correlated in all studied samples (P = .002).
Both EBV and KSHV are found in odontogenic cysts and ameloblastomas. KSHV and EBV are more prevalent in odontogenic keratocysts than in other studied odontogenic lesions. Further, there is a high prevalence of EBV and KSHV coinfection in odontogenic cysts and ameloblastomas.
牙源性病变是由于牙齿发育异常而演变而来的。本研究旨在评估 Epstein-Barr 病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV）在根囊肿、牙源性角化囊肿、牙源性釉细胞瘤中的流行情况和合并感染情况。
采用聚合酶链反应（PCR）检测 66 例牙源性病变组织中 EBV-DNA 和 KSHV-DNA 的存在情况。这些病变组织包括 15 例根囊肿、16 例牙源性角化囊肿、18 例牙源性釉细胞瘤和 17 例牙源性角化囊肿。
在所研究的样本中，检测到 24 例（36.4%） EBV-DNA，具体为：6 例（40.0%）根囊肿、4 例（25.0%）牙源性角化囊肿、10 例（55.6%）牙源性角化囊肿和 4 例（23.5%）牙源性角化囊肿（P=0.168）。在所研究的样本中，发现 16 例（24.2%） KSHV-DNA，具体为：1 例（6.7%）根囊肿、6 例（37.5%）牙源性角化囊肿、8 例（44.4%）牙源性角化囊肿和 1 例（5.9%）牙源性角化囊肿（P=0.001）。此外，在所研究的所有样本中，EBV 和 KSHV 均呈正相关（P=0.002）。
EBV 和 KSHV 均存在于牙源性囊肿和牙源性釉细胞瘤中。KSHV 和 EBV 在牙源性角化囊肿中的流行率高于其他研究的牙源性病变。此外，牙源性囊肿和牙源性角化细胞瘤中 EBV 和 KSHV 合并感染的流行率较高。
